Clinical investigation for dysphagia patients with chronic schizophrenia

2014 Fiscal Year Final Research Report

• Project/Area Number: 23592541
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Tokyo Women's Medical University (2014); Nippon Medical School (2011-2013)
• Principal Investigator: SAIGUSA Hideto 東京女子医科大学, 医学部, 講師 (70287712)
• Co-Investigator(Kenkyū-buntansha): ITOU Shigerou 日本医科大学, 医学部・大学院精神医学, 助教 (90515975) ; SHIMODA Kengo 日本医科大学, 医学部・大学院精神医学, 講師 (30277529) ; ASAYAMA Kentarou 日本医科大学, 医学部・大学院精神医学, 助教 (20373011) ; SAWAYA Atushi 日本医科大学, 医学部・大学院精神医学, 助教 (30449269) ; IKEMORI Norio 日本医科大学, 医学部・大学院精神医学 (00350041) ; KOMACHI Taro 日本医科大学, 医学部・大学院感覚器・頭頸部外科学, 助教 (10409162)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 慢性期統合失調症 / 嚥下障害 / 統合失調症

Outline of Final Research Achievements

There were some reports that patients with chronic schizophrenia (CS) were often suffering from choking,reaching near sudden death, and serious swallowing disorder. We investigated 10 case of dysphagia patients with CS. Tardive cervical dystonia and dyskinesia were seen in 5 patients, and excessive higher tonicity of cervical muscles were seen in all patients. All theirgastrointestinal motilities were disturbed. Excessive administrations could not be seen in all patients. Nutritional approaches including trans-nasal jejenum feeding were effective to improve swallowing disorder and reduced degrees of abnormal movement induced by tardive dystonia or dyskinesia. Three patients including myasthenia gravis, idiopathic myopathy of the cricopharyngeal muscle, and iatrogenic dysphagia induced by balloon expanded training to upper esophageal sphincter were improved after each treatments. Dysphagia patients with CS could be improved by scientific analysis for swallowing movements.

Free Research Field

耳鼻咽喉科学