2013 Fiscal Year Final Research Report
Gene therapy for refractory laryngeal diseases.
| Project/Area Number |
23592545
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | National Defense Medical College |
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Principal Investigator |
ARAKI Koji 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 病院, 講師 (70317220)
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| Co-Investigator(Kenkyū-buntansha) |
SHIOTANI Akihiro 防衛医科大学校, 病院, 教授 (80215946)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 遺伝子治療 / 反回神経麻痺 / 喉頭気管狭窄 / 神経再生チューブ / センダイウイルスベクター / c-myc / FIR / laser-induced shock wave |
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| Research Abstract |
We performed basic research to develop novel treatment for refractory laryngeal diseases such as (1) Recurrent laryngeal nerve (RLN) palsy and (2) Laryngotracheal stenosis (LTS).
(1) Animal model to evaluate the misdirection of nerve regeneration was established. The utility of novel nerve regeneration tube was also assessed. The basic model and techniques were established to evaluate RLN regeneration after the gene therapy for RLN palsy. (2) The rat LTS Model was established. The novel treatment for LTS using Sendai virus mediated FIR gene therapy was assessed and demonstrated preventive effect for LTS. (3) Additionally, novel gene transduction technique using LISW was also assessed and proved to be useful.
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