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2013 Fiscal Year Final Research Report

In Vivo and In Vitro Feasibility Studies of Intraocular Use of FocalSeal to Close Retinal Breaks

Research Project

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Project/Area Number 23592551
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionUniversity of Tsukuba

Principal Investigator

OKAMOTO Fumiki  筑波大学, 医学医療系, 講師 (30334064)

Project Period (FY) 2011 – 2013
Keywords網膜剥離 / シーラント / focalseal / 硝子体手術
Research Abstract

FocalSeal (FS) is an absorbable polyethylene glycol-based synthetic hydrogel sealant. This liquid is polymerized under visible xenon illumination, and forms clear, flexible, and firmly adherent hydrogel. In this study, we evaluated the intraocular biocompatibility of the sealant and explored its efficacy for closing retinal breaks, and evaluated the ability of FS to close sclerotomies of microincision vitrectomy.
Dutch pigmented normal rabbits and enucleated porcine eyes were used in this study. Adhesion of FS to the retina was relatively strong. The pH of BSS containing FS was between 7.2 to 8.0. No inflammatory reaction was observed in the eyes by ophthalmic and histological examination. There was no significant difference in the ERG between the study and control groups. FS appeared to effectively seal retinal breaks in our in vitro experiment, and the in vivo studies indicated that FS was not toxic to the eye.

  • Research Products

    (6 results)

All 2014 2013

All Presentation (6 results)

  • [Presentation] In Vivo and In Vitro Feasibility Studies of Intraocular Use of FocalSeal to Close Retinal Breaks in Porcine and Rabbit Eyes2014

    • Author(s)
      Sujin Hoshi, Fumiki Okamoto, Yuichi Kaji, Mikki Arai, Tatsuo Hirose, Tetsuro Oshika
    • Organizer
      The Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Orlando,USA
    • Year and Date
      20140504-08
  • [Presentation] FocalSeal for Closure of Sutureless Sclerotomies of Vitrectomy : An In Vivo and Histological Study2014

    • Author(s)
      Shoko ishida, Fumiki Okamoto, Sujin Hoshi, Shinichi Fukuda, Yoshimi Sugiura, Mikki Arai, Tetsuro Oshika
    • Organizer
      The Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Orlando,USA
    • Year and Date
      20140504-08
  • [Presentation] In Vivo and In Vitro Feasibility Studies of Intraocular Use of FocalSeal to Close Retinal Breaks in Porcine and Rabbit Eyes2014

    • Author(s)
      Sujin Hoshi, Fumiki Okamoto, Mikki Arai, Tatsuo Hirose, Tetsuro Oshika
    • Organizer
      World Ophthalmology Congress 2014
    • Place of Presentation
      Tokyo
    • Year and Date
      20140402-06
  • [Presentation] FocalSeal for Closure of Sutureless Sclerotomies of Vitrectomy : An In Vivo and Histological Study2014

    • Author(s)
      Rie Sato, Fumiki Okamoto, Sujin Hoshi, Mikki Arai, Tetsuro Oshika
    • Organizer
      World Ophthalmology Congress 2014
    • Place of Presentation
      Tokyo
    • Year and Date
      20140402-06
  • [Presentation] FocalSealの網膜裂孔閉鎖に対する有用性と網膜毒性の評価2013

    • Author(s)
      星崇仁、岡本史樹、杉浦好美、加治優一、新井三樹、広瀬竜夫、大鹿哲郎
    • Organizer
      第117回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      20130404-07
  • [Presentation] 小切開硝子体手術における強膜創閉鎖剤としてのFocalSealの応用2013

    • Author(s)
      岡本史樹、星崇仁、福田慎一、加治優一、新井三樹、広瀬竜夫、大鹿哲郎
    • Organizer
      第117回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      20130404-07

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Published: 2015-07-16  

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