2013 Fiscal Year Final Research Report
A chemokine receptor as a novel treatment target of age-related macular degeneration,
| Project/Area Number |
23592552
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YANAGI Yasuo 東京大学, 医学部附属病院, 講師 (90376442)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 加齢黄斑変性 / ケモカイン |
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| Research Abstract |
This study investigated the effects of inflammatory cytokine, IP-10, on choroidal neovascularization due to age-related macular degeneration. The results demonstrated that IP-10 is produced in the inflammatory macrophage and retinal pigment epithelial cells and inhibits choroidal neovascularization through its receptor, CXCR3.
This study identified a new treatment target for age-related macular degeneration, a devastating condition leading to legal blindness.
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