2013 Fiscal Year Final Research Report
Disclose the role and develop a new therapy regulating adrenergic receptor alpha 1 for retinopathy of prematurity
| Project/Area Number |
23592569
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Shigeru 神戸大学, 医学部附属病院, 講師 (60283892)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 未熟児網膜症 / アドレナリン受容体 / ノックアウトマウス |
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| Research Abstract |
To disclose the role of adrenergic receptor (ADR) alpha 1 in the development of retinopathy of prematurity (ROP) we tried to develop ADR alpha 1A, 1B and 1D knock out (KO) mice and to compare the feature of experimental ROP model (oxygen induced retinopathy) between KO mice and wild mice. Although it was very difficult to make double or triple KO mice, we have succeeded to obtain single KO mouse of each subtype. We will continue the research after this time period.
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[Journal Article] VEGF 936C>T is predictive of threshold retinopathy of prematurity in Japanese infants with a 30-week gestational age or less2011
Author(s)
Yagi M, Yamamori M, Morioka I, Yokoyama N, Honda S, Negi A, Nakamura T, Okamura N, Okumura K, Sakaeda T, Matsuo M
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Journal Title
Research and Reports in Neonatology
Volume: 1
Pages: 5-11
Peer Reviewed
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