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2013 Fiscal Year Final Research Report

research on retinal degeneration

Research Project

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Project/Area Number 23592578
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionUniversity of Miyazaki

Principal Investigator

NAOI Nobuhisa  宮崎大学, 医学部, 教授 (50211412)

Co-Investigator(Kenkyū-buntansha) CHUMAN Hideki  宮崎大学, 医学部, 准教授 (20244204)
KOZAWA Maki  宮崎大学, 医学部, 助教 (00433061)
Project Period (FY) 2011 – 2013
Keywords眼 / 網膜 / 網膜変性 / 循環障害 / 視神経 / 電気生理 / 未熟児網膜症
Research Abstract

We analysed causative genes of retinal degenertions. We have found several mutations in peripherin-RDSgene or CYP4 V2 gene of Bietti crystalline retinopathy. In x-linked retinitis pigmentosa gene patients, we analysed ORF15 region of RPGR gene and RP2 gene. In congenital retinoschisis patients with RS-1 gene mutation, we performed vitreous surgeries and reported the results.
We also established experimental model of ischemic optic neuropathy and successfully recorded STR. Recording of STR revealed innner retinal function.

  • Research Products

    (53 results)

All 2013 2012 2011

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (33 results) Book (6 results)

  • [Journal Article] 部分視神経低形成の診断から20年後に正常眼圧緑内障を発症した1例2013

    • Author(s)
      杉田直大,中馬秀樹,河野尚子,尾﨑峯生,直井信久
    • Journal Title

      眼科臨床紀要

      Volume: 6(12) Pages: 969-974

    • Peer Reviewed
  • [Journal Article] ウイルス感染が疑われ、それを契機に両眼の毛様体剥離による隅角閉塞をきたしたと思われる1例2013

    • Author(s)
      児玉悠,持原健勝,中馬秀樹,直井信久
    • Journal Title

      眼科臨床紀要

      Volume: 6(7) Pages: 557-560

    • Peer Reviewed
  • [Journal Article] Effects of steroid administration and transcorneal electrical stimulation on the anatomic and electrophysiologic deterioration of nonarteritic ischemic optic neuropathy in a rodent model2013

    • Author(s)
      T Osako, H Chuman, T Maekubo, M Ishiai, N Kawano,N Nao-i
    • Journal Title

      JJO

      Volume: 57 Pages: 410-415

    • DOI

      10.1007/s10384-012-0203-y

    • Peer Reviewed
  • [Journal Article] Effects of L-arginine on anatomical and electrophysiological deterioration of the eye in a rodent model of nonarteritic ischemic optic neuropathy2013

    • Author(s)
      H.Chuman, T Maekubo, T Osako, M Ishiai, N Kawano, N Nao-i
    • Journal Title

      JJO

      Volume: 57 Pages: 402-409

    • DOI

      10.1007/s10384-013-0250-z

    • Peer Reviewed
  • [Journal Article] Laser speckle flowgraphy for differentiating between nonarteritic ischemic optic neuropathy and anterior optic neuritis2013

    • Author(s)
      T Maekubo,H Chuman, N Nao-i
    • Journal Title

      JJO

      Volume: 57 Pages: 395-390

    • DOI

      10.1007/s10384-013-0246-8

    • Peer Reviewed
  • [Journal Article] Evaluation of inner retinal thickness around the optic disc using optical coherence tomography of a rodent model of nonarteritic ischemic optic neuropathy2013

    • Author(s)
      T Maekubo, H Chuman, Y Kodama,N Nao-i
    • Journal Title

      Jpn J Ophthalmol

      Volume: 57 Pages: 327-332

    • DOI

      10.1007/s10384-012-0195-7

    • Peer Reviewed
  • [Journal Article] Vasodilatory effects of antivascular endothelium growth factor (VEGF) antibody, corticosteroid, and nitric oxide on the posterior ciliary arteries2013

    • Author(s)
      H Chuman,N Kawano,M Kozawa,N Nao-i
    • Journal Title

      Jpn J Ophthalmol

      Volume: 57(3) Pages: 320-326

    • DOI

      10.1007/s10384-012-0179-7

    • Peer Reviewed
  • [Journal Article] 手術療法が奏効したdouble elevator palsyの一例2013

    • Author(s)
      森真喜子,中馬秀樹,河野尚子,直井信久
    • Journal Title

      眼科臨床紀要

      Volume: 6(3) Pages: 195-198

    • Peer Reviewed
  • [Journal Article] 海綿静脈洞症候群を呈したサルコイドーシスの一例2012

    • Author(s)
      小溝崇史,中馬秀樹,児玉悠,直井信久
    • Journal Title

      眼科臨床紀要

      Volume: 5(11) Pages: 1031-1035

    • Peer Reviewed
  • [Journal Article] Rodent model of nonarteritic ischemic optic neuropathy and its electrophysiological evaluation2012

    • Author(s)
      Chuman H, Maekubo T, Osako T, Kodama Y, Ishiai M, Nao-I N
    • Journal Title

      JpnJ Ophthalmol

      Volume: 56 Pages: 518-527

    • DOI

      10.1007/s10384-012-0167-y

    • Peer Reviewed
  • [Journal Article] 特発性視交叉炎の1例2012

    • Author(s)
      荻野展永,中馬秀樹,河野尚子,直井信久
    • Journal Title

      眼科

      Volume: 54(6) Pages: 785-789

    • Peer Reviewed
  • [Journal Article] 眼症状を主訴としたセネストパチーの1例2012

    • Author(s)
      松本識子,中馬秀樹,直井信久
    • Journal Title

      あたらしい眼科

      Volume: 29(4) Pages: 573-575

    • Peer Reviewed
  • [Journal Article] Application of Zen sitting principles to microscopic surgery seating2012

    • Author(s)
      Noro K, Naruse T, Lueder R, Nao-I N, Kozawa M
    • Journal Title

      Applied Ergonomics

      Volume: 43(2) Pages: 308-319

    • Peer Reviewed
  • [Journal Article] 遺伝子治療はどこまできたか眼科疾患を例として2011

    • Author(s)
      直井信久
    • Journal Title

      日州医事

      Volume: 747 Pages: 4-5

    • Peer Reviewed
  • [Presentation] Refractive Outcome of Bevacizumab Treatment of Retinopathy of Prematurity2013

    • Author(s)
      Nobuhisa Nao-i,Yoshimi Fukushima, Machi Takata
    • Organizer
      The 8^<th> APVRS Congress & The 52nd Annual Meeting of Japanese Retina and Vitreous Society
    • Place of Presentation
      愛知
    • Year and Date
      2013-12-06
  • [Presentation] 加齢黄斑変性という疾患の検査と治療~iPS細胞と今後の治療について~2013

    • Author(s)
      直井信久
    • Organizer
      加齢黄斑変性・早期発見キャンペーンin宮崎加齢黄斑変性市民フォーラム
    • Place of Presentation
      宮崎
    • Year and Date
      2013-10-13
  • [Presentation] Tamoxifen網膜症と考えられる症例の電気生理学的検討2013

    • Author(s)
      直井信久,福島慶美,荻野識子,中馬秀樹
    • Organizer
      第61回日本臨床視覚電気生理学会
    • Place of Presentation
      大阪
    • Year and Date
      2013-10-05
  • [Presentation] 最近の網膜関連の話題から2013

    • Author(s)
      直井信久
    • Organizer
      第46回鹿児島大学眼科臨床研究会
    • Place of Presentation
      鹿児島
    • Year and Date
      2013-03-09
  • [Presentation] 激症未熟児網膜症の抗VEGF治療2012

    • Author(s)
      直井信久,近藤寛之,福島慶美
    • Organizer
      第66回日本臨床眼科学会
    • Place of Presentation
      京都
    • Year and Date
      2012-10-26
  • [Presentation] Occult macular dystrophyの家族歴がある若年者の黄斑浮腫2012

    • Author(s)
      小澤摩記,直井信久
    • Organizer
      第60回日本臨床視覚電気生理学会
    • Place of Presentation
      愛知
    • Year and Date
      2012-10-05
  • [Presentation] 非動脈炎性虚血性視神経症ラットモデルに対するScotopic threshold responseを用いた治療効果の検討2012

    • Author(s)
      大迫貴子,前久保知行,杉本貴子,中馬秀樹,直井信久
    • Organizer
      第60回日本臨床視覚電気生理学会
    • Place of Presentation
      愛知
    • Year and Date
      2012-10-05
  • [Presentation] Bevacizumab treatment of retinopathy of prematurity2012

    • Author(s)
      N Nao-i,Y.Fukushima,A.Kawahara
    • Organizer
      12TH EURETINA CONGRESS
    • Place of Presentation
      Milan
    • Year and Date
      2012-09-06
  • [Presentation] The Effect of L-arginine For The Treatment of The Rodent Model Of Nonarteritic Ischemic Optic Neuropathy (r-naion)2012

    • Author(s)
      Tomoyuki Maekubo,Hideki Chuman, Michitaka Ishiai,Yuu Kodama,Takako Oosako,Takako Sugimoto,Naoko Kawano,Nobuhisa Nao-i
    • Organizer
      The 2012 ARVO Annual Meeting
    • Place of Presentation
      Fort Lauderdale
    • Year and Date
      2012-05-08
  • [Presentation] Non-arteritic Ischemic Optic Neuropathy : Animal Model Development and Treatment Applications(Basic Study)2012

    • Author(s)
      Hideki Chuman
    • Organizer
      APAO/SOE Busan2012
    • Place of Presentation
      Busan
    • Year and Date
      2012-04-16
  • [Presentation] Fundus Changes after Administration of Bevacizumab as Monotherapy in Retinopathy of Prematurity2012

    • Author(s)
      Yoshimi Fukushima,Akiteru Kawahara,Nobuhisa Naoi
    • Organizer
      APAO/SOE Busan2012
    • Place of Presentation
      Busan
    • Year and Date
      2012-04-16
  • [Presentation] Effect of Intravenous Steroid Injection on the Rodent Model of Non-arteritic Ischemic Optic Neuropathy2012

    • Author(s)
      Takako Osako,Hideki Chuman,Takako Sugimoto,Takashi Komizo,Tomoyuki Maekubo,Nobuhisa Naoi
    • Organizer
      APAO/ SOE Busan2012
    • Place of Presentation
      Busan
    • Year and Date
      2012-04-13
  • [Presentation] 暗所閾値電位による非動脈炎性虚血性視神経症ラットモデルのステロイド治療評価2012

    • Author(s)
      大迫貴子,中馬秀樹,杉本貴子,小溝崇史,前久保知行,直井信久
    • Organizer
      第116回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-07
  • [Presentation] 非動脈炎性虚血性視神経症:動物モデル作成と治療への応用2012

    • Author(s)
      中馬秀樹
    • Organizer
      第116回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-07
  • [Presentation] 非動脈炎性虚血性視神経症ラットモデルに対するOCTを用いたステロイド治療の効果検討2012

    • Author(s)
      前久保知行,中馬秀樹,河野尚子,杉本貴子,小澤摩記,川原亮輝,児玉悠,大迫貴子,石合理崇,小溝崇史,森真喜子,中山恵介,直井信久
    • Organizer
      第116回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-05
  • [Presentation] 急性期未熟児網膜症に対する抗VEGF製剤治療の前向き研究2012

    • Author(s)
      直井信久
    • Organizer
      第13回島根県眼科冬期学術講演会・第30回島根大学眼科同窓会学会
    • Place of Presentation
      島根
    • Year and Date
      2012-02-12
  • [Presentation] 遺伝子治療2011

    • Author(s)
      直井信久
    • Organizer
      第7回JRPS網脈絡膜変性フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2011-12-04
  • [Presentation] CYP4V2遺伝子変異が発見されたクリスタリン網膜症の1例2011

    • Author(s)
      小澤摩記,河野尚子,林孝彰,Jin Zi-Bing、中馬秀樹,常岡寛,直井信久
    • Organizer
      第50回日本網膜硝子体学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-12-02
  • [Presentation] The rodent model of the non-arteritic ischemic optic neuropathy(rNAION)2011

    • Author(s)
      Hideki Chuman,Tomoyuki Maekubo, Naoko Kawano,Takako Sugimoto, Takako Osako,Yuu Kodama,Michitaka Ishiai,Nobuhisa Naoi
    • Organizer
      ASNOS The Fourth Walsh in Asia
    • Place of Presentation
      兵庫
    • Year and Date
      2011-11-26
  • [Presentation] Light and Dark,Large and Small2011

    • Author(s)
      Hideki Chuman,Tomonori Hidaka, Takao Kodama,Kousuke Marutsuka, Yuichiro Sato
    • Organizer
      ASNOS The Fourth Walsh in Asia
    • Place of Presentation
      兵庫
    • Year and Date
      2011-11-25
  • [Presentation] Evaluation of the visual function in the rodent model of non-arteritic ischemic optic neuropathy(rNAION)2011

    • Author(s)
      Takako Osako,Takako Sugimoto, Tomoyuki Maekubo,Hideki Chuman, Nobuhisa Naoi
    • Organizer
      The 7th KSCEV Symposium with the 2nd JSCEV- KSCEVJoint Meeting
    • Place of Presentation
      Seoul
    • Year and Date
      2011-11-19
  • [Presentation] Fifteen year-follow up of an autosomal dominant cone-rod dystrophy pedigree associated with a Val200Glu mutation of the peripherin- RDS gene2011

    • Author(s)
      Nobuhisa Nao-i
    • Organizer
      The 2nd Japan-Korea Joint Symposium of Clinical Electrophysiology
    • Place of Presentation
      Seoul
    • Year and Date
      2011-11-19
  • [Presentation] 加齢黄斑変性を原因とする硝子体出血に対する硝子体手術の視力予後2011

    • Author(s)
      小澤摩記,中馬秀樹,直井信久
    • Organizer
      第65回日本臨床眼科学会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-09
  • [Presentation] bevacizumabを用いた未熟児網膜症の治療2011

    • Author(s)
      直井信久,近藤寛之,福島慶美
    • Organizer
      第65回日本臨床眼科学会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-08
  • [Presentation] 未熟児網膜症に対するbevacizumab投与後の眼底変化2011

    • Author(s)
      福島慶美,川原亮輝,髙田真知,中馬秀樹,直井信久
    • Organizer
      第65回日本臨床眼科学会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-07
  • [Presentation] Refractive outcome of bevacizumab treatment of retinopathy of prematurity2011

    • Author(s)
      N.Nao-i,Y.Fukushima,M.Takata,A. Kawahara
    • Organizer
      XXIX Congress of the ESCRS
    • Place of Presentation
      Vienna
    • Year and Date
      2011-09-17
  • [Presentation] 網膜硝子体疾患の最前線2011

    • Author(s)
      直井信久
    • Organizer
      第27回日本眼科看護研究会
    • Place of Presentation
      宮崎
    • Year and Date
      2011-09-11
  • [Presentation] bevacizumabによる未熟児網膜症の治療(続編)2011

    • Author(s)
      直井信久
    • Organizer
      Japan Macula Club第13回総会
    • Place of Presentation
      愛知
    • Year and Date
      2011-08-21
  • [Presentation] 急性期未熟児網膜症に対するbevacizumab治療の前向き研究2011

    • Author(s)
      直井信久,福島慶美,鮫島浩
    • Organizer
      第47回日本周産期・新生児医学会
    • Place of Presentation
      北海道
    • Year and Date
      2011-07-12
  • [Presentation] 網膜色素変性症に対するUF-021点眼液の臨床試験(PII)における微小視野計の評価2011

    • Author(s)
      山本修一,菅原岳史,中澤満,町田繁樹,村上晶,直井信久,和田裕子,三宅養三、真島行彦
    • Organizer
      第115回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-13
  • [Presentation] 網膜色素変性症に対するUF-021点眼液の臨床試験(PII):ハンフリー視野計評価2011

    • Author(s)
      菅原岳史,山本修一,中澤満,町田繁樹,村上晶,直井信久,和田裕子,三宅養三,真島行彦
    • Organizer
      第115回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-13
  • [Presentation] 網膜電図と視覚誘発電位による非動脈炎性虚血性視神経症ラットモデルの視機能評価2011

    • Author(s)
      大迫貴子,中馬秀樹,河野尚子,杉本貴子,小澤摩記,川原亮輝,前久保知行、持原健勝,石合理崇,児玉悠,髙田真知,直井信久
    • Organizer
      第115回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-12
  • [Presentation] Evaluation of the visual function in the rodent model of non-arteritic ischemic optic neuropathy(rnaion)2011

    • Author(s)
      T.Maekubo,H.Chuman,T.Oosako, M.Ishiai,Y.Kodama,A.Kawahara, T.Sugimoto,M.Kozawa,N.Kawano, N.Naoi
    • Organizer
      ARVO 2011 Annual Meeting
    • Place of Presentation
      Fort Lauderdale
    • Year and Date
      2011-05-04
  • [Book] 硝子体手術の器具・材料手術室-照明/手術台・椅子-(小椋祐一郎,門之園一明,眼手術学7網膜・硝子体I)2012

    • Author(s)
      小澤摩記,直井信久
    • Total Pages
      126-129
    • Publisher
      文光堂
  • [Book] 眼疾患説明の仕方と解説改訂3版(原著菅謙治、改訂直井信久)2012

    • Author(s)
      直井信久
    • Publisher
      金芳堂
  • [Book] 視神経乳頭小窩、専門医のための眼科診療クオリファイ7視神経疾患のすべて(中馬秀樹)2011

    • Author(s)
      直井信久
    • Total Pages
      155-159
    • Publisher
      中山書店
  • [Book] 未熟児網膜症と鑑別疾患、専門医のための眼科診療クオリファイ5全身疾患と眼(村田敏規)2011

    • Author(s)
      直井信久
    • Total Pages
      2-8
    • Publisher
      中山書店
  • [Book] 糖尿病、眼科学第2版II(監修丸尾敏夫、本田孔士、臼井正彦、編集大鹿哲郎)2011

    • Author(s)
      直井信久
    • Total Pages
      1525-1526
    • Publisher
      文光堂
  • [Book] 眼科救急疾患、今日の治療指針2011年版(山口徹、北原光夫、福井次矢)2011

    • Author(s)
      直井信久
    • Total Pages
      1257-1258
    • Publisher
      医学書院

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Published: 2015-07-16  

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