2013 Fiscal Year Final Research Report
The pupillary light reflex induced by red and blue light stimulations, and melanopsin photoreception of the rabbit.
| Project/Area Number |
23592586
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Research Collaborator |
ASAKAWA Ken 北里大学, 医療衛生学部, 助教 (60582749)
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| Project Period (FY) |
2011 – 2013
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| Keywords | メラノプシン / 網膜神経節細胞 / 対光反射 / 変異型ロドプシン遺伝子トランスジェニック家兎 |
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| Research Abstract |
Recently, a new photosensitive pigment, melanopsin, was found in 1998. Later, melanopsin-containing retinal ganglion cells (mRGCs) were discovered and revealed that mRGCs would depolarize without input from the photoreceptors, meaning that these cells were photosensitive. The mRGCs mediate the pupillary light reflex. We investigated the mechanisms of photoreception by retinal photoreceptor cells, and to evaluate the relative contribution of pupil light response using the control, pharmacological blockade of neurotransmission (PB) model and a transgenic model of retinal degeneration (Tg) rabbit. Although rod and cone photoreceptors were disappeared in the PB and Tg model, miosis was still induced during exposure to blue light (470nm). Our study also indicated that some histologically-identified RGCs were consistent with the characteristics and structures of mRGC. The greater sustained constriction of pupils to blue light in eyes with outer retinal damage reflects mRGC activation.
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[Journal Article] 神経眼科の進歩瞳孔とメラノプシンによる光受容(第116回日本眼科学会総会評議員会指名講演II)2013
Author(s)
石川均,清水公也,宇賀茂三,吉冨健志浅川賢,真下紀美代,後関利明,池田哲也,庄司信行,市邉義章,近藤峰生,寺崎浩子,奥英弘,仲泊聡,Patil Popat N,丸山茂善,中山茂信
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Journal Title
日本眼科学会雑誌
Volume: 117(3)
Pages: 246-269
URL
Peer Reviewed
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