2013 Fiscal Year Final Research Report
Early detection of macular dystrophies by Fourier-domain OCT
| Project/Area Number |
23592601
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | 独立行政法人国立病院機構(東京医療センター臨床研究センター) |
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Principal Investigator |
TSUNODA Kazushige 独立行政法人国立病院機構(東京医療センター臨床研究センター), 視覚研究部, 部長 (30255525)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 黄斑ジストロフィー / OCT |
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| Research Abstract |
The OCT could demonstrate characterisitic photoreceptor abnormalities in patients with the Occult macular dystrophy (OMD) with RP1L1 mutation; disappearance of cone outer segment tip (COST) line, and blurring or disruption of photoreceptor inner segment ellipsoid (ISe). These finding could be also observed in patients without subjective visual disturbance.
In most of the patients without the RP1L1 mutation, the OCT features were different from the above findings. Patients with OMD, who were electrophysiologically diagnosed, may harbor various etiologies other than the RP1L1 gene mutation and new diagnostic criteria should be established.
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[Presentation] オカルト黄斑ジストロフィー(Occult Macular Dystrophy)の原因遺伝子解明2011
Author(s)
赤堀正和, 角田和繁, 三宅養三, 福田陽子, 石浦浩之, 辻省次, 臼井知聡, 畑瀬哲尚, 中村誠, 大出尚郎, 板橋剛, 岡本はる, 岩田岳
Organizer
第115回日本眼科学会総会
Place of Presentation
東京
Year and Date
2011-05-13
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