2013 Fiscal Year Final Research Report
Development of a Rat Model for Retrobulbar Angiography of X-Ray Computed Tomography with an Iodine-Containing Polymer
| Project/Area Number |
23592605
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka University |
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Principal Investigator |
MATSUSHITA Kenji 大阪大学, 医学(系)研究科(研究院), 講師 (40437405)
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| Co-Investigator(Kenkyū-buntansha) |
三木 篤也 大阪大学, 助教 (30437404)
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| Co-Investigator(Renkei-kenkyūsha) |
福山 直人 東海大学, 準教授 (50349338)
静間 徹 東海大学, 専任講師 (20307523)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 医用工学 / 放射光微小血管造影法 / 緑内障 |
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| Research Abstract |
Recent adavances in optical coherence tomography allow visualization of the optic nerve structure. However, the infrared light source is limited in its ability to analyze the retrobulbar structure because of insufficient penetration; in contrast, X-rays can penetrate deeper. We developed a model for retrobulbar angiography with computed tomography to reveal the retrobulbar structures around the optic nerve head. Four-week-old SD rats were observed alive with CT. Trough the catheter, we had injected a contrast agent, iohexol and an iodine-containing polymer solution. After contrast agent washout, the CT values were recorded at baseline, maximal contrast agent enhancement, washout, and maximal iodine-containing polymer enhancement. We localized the area governed by ICA. The polymer stayed in the eye after the contrast was flushed from the orbit. We developed a model for retrobulbar angiography that makes it easy to adjust the imaging conditions.
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Research Products
(16 results)
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[Journal Article] Circle- and grid-wise analyses of peripapillary nerve fiber layers by spectral domain optical coherence tomography in early-stage glaucoma2013
Author(s)
Mayama C,Saito H, Hirasawa H, Konno S, Tomidokoro A, Araie M, Iwase A, Ohkubo S, Sugiyama K, Otani T, Kishi S, Matsushita K, Maeda N, Hangai M, Yoshimura N
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 54(7)
Pages: 4519-26
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[Journal Article] A case of aniridia with a heterozygous PAX6 mutation whose pituitary function was partially impaired2013
Author(s)
Shimo N, Yasuda T, Kitamura T, Matsushita K, Osawa S, Yamamoto Y, Kozawa J, Otsuki M, Funahashi T, Imagawa A, Kaneto H, Nishida K, Shimomura I
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Journal Title
Internal medicine
Volume: (on publication)
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[Journal Article] Reproducibility of Thickness Measurements of Macular Inner Retinal Layers Using SD-OCT with or without Correction of Ocular Rotation2013
Author(s)
Hirasawa H, Araie M, Tomidokoro A, Saito H, Iwase A, Ohkubo S, Sugiyama K, Ootani T, Kishi S, Matsushita K, Maeda N, Hangai M, Yoshimura N
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 54(4)
Pages: 2562-70
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[Journal Article] Effects of age, sex, and axial length on the three-dimensional profile of normal macular layer structures2011
Author(s)
Ooto S, Hangai M, Tomidokoro A, Saito H, Araie M, Otani T, Kishi S, Matsushita K, Maeda N, Shirakashi M, Abe H, Ohkubo S, Sugiyama K, Iwase A, Yoshimura N
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Journal Title
Ophthalmol Vis Sci
Volume: 52(12)
Pages: 8769-79
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