2013 Fiscal Year Final Research Report
Neuroprotection of experimental autoimmune optic neuritis by retinoid
| Project/Area Number |
23592615
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 視神経炎 / レチノイド |
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| Research Abstract |
In the present study, we investigated whether all trans-retinoic acid (ATRA) can reduce the degree of experimental autoimmune optic neuritis (EAON) in mice. Optic neuritis was induced in C57BL/6 mice by immunizing them with myelin oligodendrocyte glycoprotein35-55. ATRA (350 ug/mouse/time point) was administered every other day from day 0 to day 20. ATRA treatment significantly reduced the clinical score of EAE and the severity of the optic neuritis by histopathological analysis. The production of IFN-g and IL-17 by draining lymph node cells was significantly reduced in ATRA-treated mice. The degree of demyelination in the optic nerve of mice with EAE was significantly reduced after ATRA treatment. These findings demonstrate that ATRA treatment was able to reduce the severity of optic neuritis in mice with EAE.
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