2013 Fiscal Year Final Research Report
The effect of omega-3 fatty acids on hepatic stellate cell activation
| Project/Area Number |
23592623
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Akita University |
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Principal Investigator |
YOSHINO Hiroaki 秋田大学, 医学(系)研究科(研究院), 准教授 (90182807)
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| Co-Investigator(Kenkyū-buntansha) |
MORII Mayako 秋田大学, 医学部, 助教 (10375280)
HEBIGUCHI Taku 秋田大学, 医学部, 医員 (20375281)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ω3系脂肪酸 / 肝臓星細胞 |
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| Research Abstract |
Hepatic stellate cells (HSCs) store vitamin A and they are also known to be responsible for liver fibrosis. In child short bowel patients, oral administration of omega-3 fatty acids reduced the number of activated HSCs. Using HSCs isolated and cultured from rat liver, addition of omega-3 fatty acids accelerated formation of lipid droplets and decreased the expression levels of alpha-smooth muscle actin and type I collagen mRNAs.
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[Presentation] ヤツメウナギにおける胆汁排泄機構2013
Author(s)
森井真也子,目崎喜弘,吉川究,山口典子,三浦光隆,今井克幸,蛇口琢,渡部亮,妹尾春樹,吉野裕顕
Organizer
第118回日本解剖学会総会・全国学術集会
Place of Presentation
高松, 香川
Year and Date
2013-03-30
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[Presentation] 腸管不全合併肝障害ラットモデルの作製2013
Author(s)
Hebiguchi T., Morii M., Watanabe R., Mezaki Y., Senoo H., Yoshino H., Imai K., Miura M., Yoshikawa K., Yamaguchi N
Organizer
第118回日本解剖学会総会・全国学術集会
Place of Presentation
高松, 香川
Year and Date
2013-03-28
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[Presentation] 胆道閉鎖症患児に対するω-3系脂肪製剤投与の経験2012
Author(s)
森井真也子,蛇口琢,渡部亮,吉野裕顕,目崎喜弘,山口典子,吉川究,今井克幸,三浦光隆,妹尾春樹
Organizer
第49回日本小児外科学会学術集会
Place of Presentation
横浜,神奈川
Year and Date
2012-05-16
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[Presentation] The metabolism of cholesterol after bile duct degeneration in lamprey2012
Author(s)
Morii M., Mezaki Y., Yamaguchi N., Yoshikawa K., Imai K., Miura M., Yoshino H., Hebiguchi T., Asanuma Y., Hebiguchi T., Senoo H
Organizer
第117回日本解剖学会総会・全国学術集会
Place of Presentation
甲府,山梨
Year and Date
2012-03-27
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[Presentation] Reversibility of periductal fibrosis during biliary atresia in the lamprey2011
Author(s)
Morii M., Yoshino H., Hebiguchi T., Mezaki Y., Yamaguchi N., Yoshikawa K., Miura M., Imai K., Senoo H., Hebiguchi T
Organizer
16th International Symposium on Cells of Hepatic Sinusoid
Place of Presentation
Florence, Italy
Year and Date
2011-09-23
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[Presentation] ω3系脂肪製剤を使用した,短腸症候群2例の経験2011
Author(s)
森井真也子, 吉野裕顕, 蛇口琢, 目崎喜弘, 山口典子, 吉川究, 三浦光隆, 今井克幸, 妹尾春樹, 蛇口達造
Organizer
第48回日本小児外科学会学術集会
Place of Presentation
東京
Year and Date
2011-07-22
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[Presentation] 腸管不全合併肝障害にω3系脂肪製剤が著効した短腸症候群の2例2011
Author(s)
森井真也子,吉野裕顕,和田基,蛇口琢,目崎喜弘,山口典子,吉川究,三浦光隆,今井克幸,妹尾春樹,仁尾正記,蛇口達造
Organizer
日本外科代謝栄養学会第48回学術集会
Place of Presentation
名古屋,愛知
Year and Date
2011-07-08
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