2013 Fiscal Year Final Research Report
Tracheoplasty by combined growth factor and injectable cell therapy
| Project/Area Number |
23592625
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Pediatric surgery
|
|---|
| Research Institution | Saitama Medical University (2012-2013)
The University of Tokyo (2011) |
|---|
Principal Investigator |
KOMURA Makoto 埼玉医科大学, 医学部, 教授 (10422289)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TABATA Yasuhiko 京都大学, 再生医科学研究所, 教授 (50211371)
IWANAKA Tadashi 東京大学, 医学部附属病院, 教授 (90193755)
星 和人 東京大学, 医学部附属病院, 准教授 (30344451)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 再生医療 / 気道再建 / 成長因子 |
|---|
| Research Abstract |
A gelatin sponge with slowly releasing basic fibroblast growth factor (b-FGF) enhances chondrogenesis. This study investigated the optimal amount of basic fibroblast growth factor (b-FGF) in gelatin sponges to fabricate engineered cartilage. Gelatin sponges impregnated with more than 100micrpg/ml b-FGF incorporating beta-TCP with chondrocytes (10x10e6cells/ml) can fabricate engineered cartilage at 4 weeks after implantation. We devised a new tracheoplasty using a cartilage graft engineered outside the esophagus. This study investigated the feasibility of fabricating cartilage engineered outside the esophagus and using it to perform tracheoplasty in a rabbit model. Tracheoplasty with cartilage engineered outside the esophagus may be useful for developing reconstructed airways.
|
