The establishment of the novel immunotherapy for neuroblastoma using transgenic mouse

2014 Fiscal Year Final Research Report

• Project/Area Number: 23592631
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatric surgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: TAJIRI TATSURO 京都府立医科大学, 医学(系)研究科(研究院), 教授 (80304806)
• Co-Investigator(Kenkyū-buntansha): TGUCHI Tomoaki 九州大学, 医学(系)研究科, 教授 (20197247) ; YONEMITSU Yosikazu 九州大学, 薬学研究科, 教授 (40315065) ; KADOMATSU Kenji 名古屋大学, 医学(系)研究科, 教授 (80204519)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 小児がん / 神経芽腫 / 免疫治療 / センダイウイルス / 樹状細胞

Outline of Final Research Achievements

To establish the novel treatment for neuroblastoma, we assessed the anti tumor effect and the analysis of mechanism of the immunotherapy with local radiation by Sendai Virus/Dendritic cel for neuroblastoma using MYCN transgenic mouse. The anti tumor effect for neuroblastoma of he immunotherapy with local radiation by SeV/DC was demonstrated. The possibility was suggested that the NK cell and CD4 positive T-cell was the primitive effector cells for this immunotherapy.

Free Research Field

小児外科