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2013 Fiscal Year Final Research Report

Development of a novel system of the gene therapy for peripheral arterial diseases.

Research Project

  • PDF
Project/Area Number 23592638
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Plastic surgery
Research InstitutionTohoku University

Principal Investigator

TAKEDA Atsushi  東北大学, 大学病院, 助教 (30333800)

Project Period (FY) 2011 – 2013
Keywords血管新生療法 / 下肢虚血モデル / マウス下肢血管解剖
Research Abstract

To develop novel gene therapies limited in targeted sites for peripheral arterial diseases, we studied the murine hindlimb ischemia model used in the treatment experiment. There it became apparent that not only appropriate therapeutic target sites in each ischemia model, but also details of vascular anatomy in murine lindlimb are not revealed and considered enough. So, clarify the structure of the vascular network, and verified the relationship between the optimal treatment sites and model fabrication method by observing in detail the murine hindlimb arterial anatomy. These observations will contribute to development of angiogenetic therapies as a basic knowledge for designing therapeutic experiment of limb ischemias into the future. These results were published in English on-line journal (PlosOne), and as a thesis (Doctor of Medicine).

  • Research Products

    (4 results)

All 2013 2012 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Characterization of the Arterial Anatomy of the Murine Hindlimb : Functional Role in the Design and Understanding of Ischemia Models2013

    • Author(s)
      Takashi Kochi, Yoshimichi Imai, Atsushi Takeda, Yukiko Watanabe, Shiro Mori, Masahiro Tachi, Tetsuya Kodama
    • Journal Title

      PLoS One

      Volume: 8(12) Pages: e84047

    • DOI

      10.1371/journal.pone.0084047

    • Peer Reviewed
  • [Presentation] マウス下肢虚血モデル作成術式による血管密度変化部位の差の検討2013

    • Author(s)
      高地崇, 武田睦, 今井啓道, 館正弘
    • Organizer
      第22回日本形成外科学会基礎学術集会
    • Place of Presentation
      新潟
    • Year and Date
      2013-11-07
  • [Presentation] 音響性リポソームと高周波超音波装置による微小血流計測の試み2012

    • Author(s)
      高地崇, 武田睦, 今井啓道, 館正弘
    • Organizer
      第21回日本形成外科学会基礎学術集会
    • Place of Presentation
      福島
    • Year and Date
      2012-10-04
  • [Presentation] 血管解剖に基づいたマウス下肢虚血モデルの作製2011

    • Author(s)
      高地崇, 武田睦, 今井啓道, 館正弘
    • Organizer
      第20回日本形成外科学会基礎学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-06

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Published: 2015-07-16  

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