2013 Fiscal Year Final Research Report
Development of the novel therapeutic modality for hyperplastic scar and keloid using short chain fatty acids and polyunsaturated fatty acids
| Project/Area Number |
23592648
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Kobe University |
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Principal Investigator |
USAMI Makoto 神戸大学, 保健学研究科, 教授 (00193855)
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| Co-Investigator(Kenkyū-buntansha) |
TERASHI Hiroto 神戸大学, 医学部附属病院形成外科, 教授 (80217421)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIKAWA Michiko (AOYAMA Michiko) 神戸大学, 保健学研究科, 保健学研究員 (40566121)
MAESHIGE Noriaki 神戸大学, 保健学研究科, 助教 (90617838)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 創傷治癒学 |
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| Research Abstract |
We revealed the antifibrogenic effects of short chain fatty acids and polyunsaturated fatty acids, and the best combination is butyrate and docosahexaenoic acid among those fatty acids. As the mechanisms, we found the inhibitory effects on the expressions of profibrotic factors including alpha-SMA, TGF-beta1, type I collagen and type III collagen, and the inhibition of cell proliferation, and promotion of apoptosis in normal human dermal and keloid fibroblasts. These antifibrogenic effects were also found in the pathological models with addition of proinflammatory cytokines or pseudomonas aeruginosa derived LPS or TGF-beta1 stimulation. As the key mechanisms of these effects, the production of PGE2, as an antifibrogenic lipid mediator, and the histone acetylation by butyrate were revealed.
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[Presentation] Antifibrogenic and proapoptotic effects of butyrate/DHA via PGE_2 secretion on keloid fibroblasts in inflammatory model2013
Author(s)
Noriaki Maeshige, Kazuhiro Torii, Hiroto Tabuchi, Ayumi Saka, Kyoko Araki, Michiko Aoyama Ishikawa, Midori Imai, Yuka Koga, Akane Ochi, Mikiko Uemura, Makoto Miyoshi, Yasuhiro Hamada, Hiroto Terashi, Makoto Usami
Organizer
35th Congress of the European Society of Clinical Nutrition and Metabolism
Place of Presentation
Leipzig
Year and Date
2013-09-01
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