Researches for wound healing using a hybrid type artificial skin model retrofitted with human immune cells

2014 Fiscal Year Final Research Report

• Project/Area Number: 23592656
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Showa University
• Principal Investigator: KAO BUNSHO 昭和大学, 医学部, 講師 (10327893)
• Co-Investigator(Kenkyū-buntansha): KADOMATSU Koichi 昭和大学, 医学部, 講師 (90317529)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: ヒト皮膚モデル

Outline of Final Research Achievements

This study investigated the behavior of inflammatory cells in the wound healing process in human skin using a new artificial skin model with macrophages. According to the new laws of regenerative medicine in Japan, we have revised our protocol for construction process of making artificial skin model.
After this revision, the monocytes changed to macrophages in the samples as the previous model. Also the number of macrophages increased and the size was larger after laser irradiation. The macrophages were activated both in the irradiated area and in the whole sample as well.
In conclusion, this new artificial skin model with macrophages demonstrated increased tissue interactions, especially in inflammatory reactions.

Free Research Field

再生医療