Influence of atropine and pralidoxime on organophosphorus cholinesterase inhibitors-induced epileptic activity

2015 Fiscal Year Final Research Report

• Project/Area Number: 23592675
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Sapporo Medical University
• Principal Investigator: NARIMATSU EICHI 札幌医科大学, 医学部, 教授 (70295343)
• Co-Investigator(Kenkyū-buntansha): NIIYA Tomohisa 札幌医科大学, 医学部, 講師 (80510312) ; KAWAMATA Mikito 信州大学, 医学部, 教授 (90315523) ; YAMAUCHI Masanori 東北大学, 医学(系)研究科(研究院), 教授 (00404723)
• Project Period (FY): 2011-04-28 – 2016-03-31
• Keywords: 有機リン / コリンエステラーゼ阻害薬 / てんかん / 海馬 / アトロピン / プラリドキシム / 抗痙攣薬 / 中毒

Outline of Final Research Achievements

We investigated the epilepsy-inducing actions of paraoxon with elevated [K+]e and the effects of atropine, pralidoxime, and selective muscarinic acetylcholine receptor (mAChR) antagonists on the actions of paragon.
paraoxon-induced cholinesterase inhibition elicited epileptic activity in elevated [K+]e but not normal [K+]e. Treatment for hyperkalemia likely prevents the development of epilepsy in organophosphate intoxication. Paraoxon-induced epileptic activity was inhibited by atropine but not by pralidoxime. Relatively weak mAChR activation likely elicited epileptic activity in 7.5 mM [K+]e. Atropine, rather than pralidoxime, may be effective at inhibiting organophosphate-induced epileptic activity.

Free Research Field

救急医学