2013 Fiscal Year Final Research Report
Establishment of iPS cell lines from dental pulp cells using Sendai virus vectors
| Project/Area Number |
23592697
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Gifu University |
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Principal Investigator |
TEZUKA Ken-ichi 岐阜大学, 医学(系)研究科(研究院), 准教授 (50236973)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 歯髄細胞 / iPS細胞 / センダイウイルスベクター / HLAタイプ / 再生医療 |
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| Research Abstract |
For application of iPS cells for clinical use, safer methods without vector integration are being established. Recently, we used episomal plasmid vector system for this purpose, and succeeded to establish multiple lines in collaboration with Kyoto University. One of the lines were submitted to RIKEN BRC and started to be distributed to other researchers. In this research, we tried to use Sendai virus vector systems to establish iPS cells homozygous for human leukocyte antigens (HLAs). We also tried serum-free method for culturing the cells, and succeeded to establish multiple iPS cell lines.
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Research Products
(17 results)
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[Presentation] Dental Pulp Cells as Souce for iPS Cell Banking2013
Author(s)
Ken-ichi Tezuka, Tomoko Kawaguchi, Naritaka Tamaoki, Kazuki Iida, Hitomi Aoki, Toshiyuki Shibata, Takahiro Kunisada
Organizer
2013 Annual Meeting of the American Society for Bone and Mineral Research
Place of Presentation
Baltimore
Year and Date
20131004-07
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