• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2013 Fiscal Year Final Research Report

Establishment of bone invasion model by oral cancer and effects of NF-kB inhibitor on bone invasion.

Research Project

  • PDF
Project/Area Number 23592707
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Morphological basic dentistry
Research InstitutionKyushu Dental College

Principal Investigator

MATSUO Kou  九州歯科大学, 歯学部, 准教授 (70238971)

Co-Investigator(Kenkyū-buntansha) JIMI Eijiro  九州歯科大学, 歯学部, 教授 (40276598)
Co-Investigator(Renkei-kenkyūsha) AOKI Kazuhiro  東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (40272603)
Project Period (FY) 2011 – 2013
Keywords口腔癌 / 顎骨浸潤 / NF-κB
Research Abstract

Nuclear factor-kB (NF-kB) is constitutively activated in many cancers, including oral squamous cell carcinoma (OSCC). However, the cellular mechanism underlying NF-kB's promotion of bone invasion by OSCC is unclear. Therefore, we investigated the role of NF-kB in bone invasion by OSCC in vivo. Immunohistochemical staining of OSCC invading bone in 10 patients indicated that the nuclear translocation of NF-kB was increased in OSCC compared with normal squamous epithelial cells. We next injected mouse OSCC SCCVII cells into the masseter region of C3H/HeN mice. Treatment with NBD peptide, a selective NF-kB inhibitor, decreased zygoma and mandible destruction by SCCVII cells, reduced number of osteoclasts by inhibiting RANKL expression in osteoblastic cells and SCCVII cells, increased apoptosis and suppressed the proliferation of SCCVII cells. Taken together, our data clearly indicate that inhibition of NF-kB is useful for inhibiting bone invasion by OSCC

  • Research Products

    (18 results)

All 2014 2013 2012 2011

All Journal Article (9 results) Presentation (9 results)

  • [Journal Article] The RANKL/RANK system as a therapeutic target for bone invasion by oral squamous cell carcinoma (Review)2013

    • Author(s)
      Jimi E, Shin M, Furuta H, Tada Y, Kusukawa J
    • Journal Title

      Int J Oncol

      Volume: 42(3) Pages: 803-9

  • [Journal Article] Multiple complex odontomas and subsequent occurrence of an ossifying fibroma at the same site as the removed odontoma2013

    • Author(s)
      Matsuo K, Yamamoto N, Morimoto Y, Yamashita Y, Zhang M, Ishikawa A, Tanaka T, Kito S, Takahashi T
    • Journal Title

      J Dent Sci

      Volume: 8 Pages: 189-195

  • [Journal Article] Effects of thymosinβ10 andβ15 on wound healing in rat tooth extraction sockets2013

    • Author(s)
      Akasakia Y, Matsuo K, Adachi K, Ishikawa A, Zhang M, Hosokawa R
    • Journal Title

      J Oral Maxillofac Surg Med Pathol

    • DOI

      10.1016/j.ajoms.2013.02.007

  • [Journal Article] Effects of thymosinβ4 on the healing process of calvarial defects in rat2013

    • Author(s)
      Adachi K, Matsuo K, Akasaki Y, Kanao M, Maeda T, Ishikawa A, Hosokawa R
    • Journal Title

      J Prosthodont Res

      Volume: 57 Pages: 162-168

  • [Journal Article] ラット抜歯窩の治癒に対するウシラクトフェリンの効果2013

    • Author(s)
      松本ゆかり、村岡宏祐、松尾拡、中島啓介
    • Journal Title

      九州歯会誌

      Volume: 67 (1) Pages: 5-12

  • [Journal Article] Promoting effects of thymosinβ4 on granulation tissue and new bone formation after tooth extraction in rats2012

    • Author(s)
      Matsuo K, Akasaki Y, Adachi K, Zhang M, Ishikawa A, Jimi E, Nishihara T, Hosokawa R
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod

      Volume: 114 Pages: 17-26

  • [Journal Article] Selective inhibition of NF-κB suppresses bone invasion by oral squamous cell carcinoma in vivo2011

    • Author(s)
      Furuta H, Osawa K, Shin M, Ishikawa A, Matsuo K, Kahn M, Aoki K, Ohya K, Okamoto M, Tominaga K, Takahashi T, Nakanishi O, Jimi E
    • Journal Title

      Int J Cancer

      Volume: 131 Pages: E625-635

  • [Journal Article] The inhibition of RANKL/RANK signaling by osteoprotegerin suppresses bone invasion by oral squamous cell carcinoma cells2011

    • Author(s)
      Shin M, Matsuo K, Tada T, Fukushima H, Furuta H, Ozeki S, Kadowaki T, Yamamoto K, Okamoto M, Jimi E
    • Journal Title

      Carcinogenesis

      Volume: 32 Pages: 1634-1640

  • [Journal Article] The cellular and molecular mechanisms of bone invasion by oral squamous cell carcinoma2011

    • Author(s)
      Jimi E, Furuta H, Matsuo K, Tominaga K, Takahashi T, Nakanishi O
    • Journal Title

      Oral Diseases

      Volume: 17 Pages: 462-468

  • [Presentation] New selective inhibitor of NF-κB inhibits bone invasion by oral squamous cell carcinoma2014

    • Author(s)
      Tada Y, Sugiyama G, Watanabe S, Jimi E
    • Organizer
      ASIA-PACIFIC CONFERENCE
    • Place of Presentation
      九州歯科大学講堂
    • Year and Date
      2014-01-25
  • [Presentation] 新規NF-κB選択的阻害剤は口腔癌による顎骨浸潤を抑制する2013

    • Author(s)
      多田幸代、福島秀文、大澤賢次、自見英治郎
    • Organizer
      第55回歯科基礎医学会学術大会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      20130920-22
  • [Presentation] NF-κB選択的阻害剤による口腔扁平上皮癌顎骨浸潤抑制の分子メカニズム解析2013

    • Author(s)
      多田幸代、福島秀文、大澤賢次、渡邉誠之、自見英治郎
    • Organizer
      第73回九州歯科学会総会学術大会
    • Place of Presentation
      九州歯科大学講堂
    • Year and Date
      20130518-19
  • [Presentation] 口腔扁平上皮癌による顎骨浸潤におけるNF-κBの役割2012

    • Author(s)
      多田幸代、古田弘之、自見英治郎
    • Organizer
      第72回九州歯科学会
    • Place of Presentation
      北九州
    • Year and Date
      20120518-19
  • [Presentation] 口腔扁平上皮癌の顎骨浸潤モデルの確立とNF-κB阻害剤による顎骨浸潤抑制効果の検討2012

    • Author(s)
      自見英治郎、古田弘之、松尾拡、冨永和宏、高橋哲、仲西修
    • Organizer
      第72回九州歯科学会
    • Place of Presentation
      北九州
    • Year and Date
      20120518-19
  • [Presentation] Beta-thymosinsの歯科臨床応用を目指す基礎的研究2012

    • Author(s)
      松尾拡、鷲尾絢子、北村知昭、自見英治郎、西原達次
    • Organizer
      第72回九州歯科学会
    • Place of Presentation
      北九州
    • Year and Date
      20120518-19
  • [Presentation] 糖尿病性歯周炎発症の分子機構の解明と治療薬開発のための基礎研究2012

    • Author(s)
      張皿、松尾拡、中道郁夫、自見英治郎
    • Organizer
      第72回九州歯科学会
    • Place of Presentation
      北九州
    • Year and Date
      20120518-19
  • [Presentation] 口腔扁平上皮癌細胞による顎骨浸潤におけるNF-κBの役割とNF-κBの選択的阻害剤を用いた顎骨浸潤抑制効果2012

    • Author(s)
      自見英治郎
    • Organizer
      第15回癌と骨病変研究会
    • Place of Presentation
      千代田放送会館、東京
    • Year and Date
      2012-11-02
  • [Presentation] 口腔扁平上皮癌による顎骨浸潤におけるNF-κBの役割2012

    • Author(s)
      多田幸代、福島秀文、大澤賢次、自見英治郎
    • Organizer
      第54回日本歯科基礎医学会
    • Place of Presentation
      奥羽大学、福島
    • Year and Date
      2012-09-15

URL: 

Published: 2015-07-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi