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2013 Fiscal Year Final Research Report

The neurogenic regulation for the initial bone formation in mandibular bone.

Research Project

  • PDF
Project/Area Number 23592708
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Morphological basic dentistry
Research InstitutionKyushu Dental College

Principal Investigator

KOAYASHI SHIGERU  九州歯科大学, 歯学部, 教授 (10118078)

Co-Investigator(Kenkyū-buntansha) GOTO Tetsuya  九州歯科大学, 歯学科, 准教授 (70253458)
KATAOKA Shinnji  九州歯科大学, 歯学科, 助教 (80364149)
Project Period (FY) 2011 – 2013
KeywordsiPS細胞 / 神経 / 神経ペプチド / 細胞分化 / 間葉系幹細胞 / 骨芽細胞
Research Abstract

To confirm the involvement of nerves for bone formation were examined for altered expression of the receptor of neuropeptides in the process to become osteoblasts from iPS cells. During three stage of cell differentiation; iPS, embryonic body, and osteoblast, the cells in iPS stage and early osteoblastic stage, the beta 2 adrenergic receptors and CGRP receptor were specifically expressed, and the NK-1 receptor is expressed specifically in the late differentiation of osteoblasts. These results suggest that neuropeptides affect the differentiation of osteoblast as the differentiation stage-dependent manner.

  • Research Products

    (5 results)

All 2013 2012

All Presentation (5 results)

  • [Presentation] マウスiPS細胞の骨芽細胞分化における交感神経・知覚神経の関与について2013

    • Author(s)
      長尾怜美、後藤哲哉、小林繁
    • Organizer
      日本解剖学会第69回九州支部学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      20131100
  • [Presentation] マウスiPS細胞から骨芽細胞への分化過程における神経ペプチドレセプターの発現について2013

    • Author(s)
      後藤哲哉
    • Organizer
      第50回日本口腔組織培養学会
    • Place of Presentation
      東京
    • Year and Date
      20131000
  • [Presentation] マウスiPS細胞の骨芽細胞分化過程における神経ペプチドレセプターの発現について2013

    • Author(s)
      長尾怜美、後藤哲哉、江草宏、矢谷博文、小林繁、牧憲司
    • Organizer
      第55回歯科基礎医学会総会
    • Place of Presentation
      岡山
    • Year and Date
      20130900
  • [Presentation] Hemokinin 1はsubstance Pの骨形成促進作用を抑制する2012

    • Author(s)
      小早川美輝、牧角有華、小林繁、後藤哲哉
    • Organizer
      第54回歯科基礎医学会総会
    • Place of Presentation
      郡山
    • Year and Date
      20120900
  • [Presentation] マウスiPS細胞の骨芽細胞分化におけるレチノイン酸の影響について2012

    • Author(s)
      長尾怜美、後藤哲哉、中川綾子、小林繁、牧憲司
    • Organizer
      第72回九州歯科学会
    • Place of Presentation
      北九州市
    • Year and Date
      20120000

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Published: 2015-07-16  

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