2013 Fiscal Year Final Research Report
Mechanism and significance of Meckel's cartilage disappearance
| Project/Area Number |
23592710
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Meikai University |
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Principal Investigator |
AMANO Osamu 明海大学, 歯学部, 教授 (60193025)
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| Project Period (FY) |
2011 – 2013
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| Keywords | メッケル軟骨 / 細胞死 / アポトーシス / オートファジー / 脂肪酸結合タンパク質 |
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| Research Abstract |
During the development of mouse Meckel's cartilage, apoptosis was detected limitedly at 1) the mesenchymal condensation and 2) the perichondrium. No apoptotic cells were found in Meckel's chondrocytes; therefore, apoptosis does not participate in the degeneration of Meckel's cartilage. Because substantial proliferation and differentiation occur in the area of 1) and 2), apoptosis may play important roles in chondroblast differentiation for the development of Meckel's cartilage. Inhibition of apoptosis induced the dysplasia of Meckel's cartilage. In addition, immunolocalization of fatty acid-binding protein (FABP) in Meckel's and the growth plate cartilages, epidermal type FABP was exclusively expressed in the septoclast, a absorbing cells of uncalcified cartilage matrix.
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