2013 Fiscal Year Final Research Report
Establishment of salivary gland regeneration for salivary gland hypofunction : Approach to regeneration of blood vessels using dental pulp cells
| Project/Area Number |
23592719
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Ichiro 鶴見大学, 歯学部, 教授 (60147634)
MISHIMA Kenji 昭和大学, 歯学部, 教授 (50275343)
HAMADA Yoshiki 鶴見大学, 歯学部, 教授 (70247336)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 口腔病理学 / 唾液腺の再生 / 血管新生 |
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| Research Abstract |
Radiation-induced salivary gland hypofunction might be treated by regenerating blood vessels using cell transfer therapy. Then, we examined the availability of dental pulp cells (DPCs) which could be used as a cell source of endothelial cells. As a result, dental pulp cells contained cells retaining endothelial functions. Our results show that radiation-induced salivary hypofunction is partially reverted by transplantation of endothelial cell-induced DPCs. For these reasons, DPCs could be used as a cell source for the treatment of salivary gland hypofunction.
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