2013 Fiscal Year Final Research Report
The study of chondrocyte cell differentiation mechanism induced by amelogenin
| Project/Area Number |
23592726
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | アメロジェニン / 軟骨 |
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| Research Abstract |
Amelogenin is one of proteins in enamel matrices and promotes chondrogenesis. However it has been still unknown the mechanism of chondrogenesis by amelogenin. In this study, we have newly made a chemical artificial synthesized leucin rich amelogenin peptide (LRAP), which is one of amelogenin splicing isoforms, and this synthesized LRAP promoted the cell proliferation of mouse chondrocytes compared with control significantly. Furthermore enamel matrix derivative (EMD) derived from porcine tooth germ including LRAP promoted chondrogenesis involving LAMP-1 (Lysosome associated membrane protein-1), which has been reported the amelogenin binding protein and suggested as signaling receptor of amelogenin. These results may provide useful information to promote the development of the cartilage regeneration.
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