2013 Fiscal Year Final Research Report
Promotion of bone formation using chondroitin sulfate E and application to bone regenerating biomaterials
| Project/Area Number |
23592728
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Functional basic dentistry
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
MIYAZAKI Tatsuya 東北大学, 歯学研究科(研究院), 大学院非常勤講師 (90538638)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Osamu 東北大学, 大学院歯学研究科, 教授 (60374948)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
ANADA Takahisa 東北大学, 大学院歯学研究科, 准教授 (30398466)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | コンドロイチン硫酸 / インテグリン / オステオアクチビン / 破骨細胞 / 骨形成 |
|---|
| Research Abstract |
Chondroitin sulfate E enhances osteoblast differentiation and inhibits osteoclast differentiation. As a mechanism of action, it was demonstrated that CS-E bound to adhesion molecules such as both osteoactivin (OA) and its receptor, integrin. And also CS-E inhibited the osteoclast differentiation by blocking the interaction of OA to integrin and heparan sulfate. On the other hands, osteoblast produced biglycan core protein and E-unit of CS. The amount of these molecules transiently increased before osteoblast differentiation (mineralization). These results indicated that not only the exogenously-added CS-E but also endogenous CS contributed the differentiation of the cells. Based on the results in the present study, we will further investigate the potentiality of CS-E as an application to bone regenerating biomaterials.
|
