2013 Fiscal Year Final Research Report
The relationship between local anesthetic effect of QX-314 and TRPV1 expression following inferior alveolar nerve transection in rats
| Project/Area Number |
23592730
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMURA Kensuke 新潟大学, 医歯学系, 教授 (90272822)
YAMADA Yoshiaki 新潟大学, その他, 理事 (80115089)
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| Project Period (FY) |
2011 – 2013
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| Keywords | QX-314 / TRPV1 / カプサイシン / 神経障害性疼痛 / 神経損傷 / C 線維 / 痛覚 |
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| Research Abstract |
QX-314 with capsaicin has been reported to produce long-lasting block of acute pain. However, little is reported of their effectiveness on neuropathic pain (NP) after nerve injury which involves various biophysical and molecular changes in sensory neurons. In this study the effect of this combination was evaluated under NP and non-NP conditions after inferior alveolar nerve (IAN) transection.
The magnitude of QX-314 with capsaicin induced local anesthetic block varied under various conditions; however, no block was observed under NP conditions at 2 weeks after transection. Immunohistochemical study revealed that the number of regenerated neurons with transient receptor potential vanilloid 1 (TRPV1) expression gradually increased over time after transection. Unmyelinated neurons expressing TRPV1 regenerated slowly, especially in the presence of NP. In addition, TRPV1 expression shifted to myelinated fibers and this shift was more intense under NP than under non-NP conditions.
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[Journal Article] Expression of TRPV1 channels after nerve injury provides an essential delivery tool for neuropathic pain attenuation2012
Author(s)
Zakir HM, Mostafeezur RM, Suzuki A, Suzuro Hitomi S, Suzuki I, Takeyasu Maeda T, Seo K, Yamada Y, Yamamura K, Lev S, Binshtok AM, Iwata K, Kitagawa J
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Journal Title
PloS ONE
Volume: 7(9)
Pages: e44023
DOI
Peer Reviewed
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