• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2013 Fiscal Year Final Research Report

The study on the expression of monoamine transporters after onset of neuropathic pain

Research Project

  • PDF
Project/Area Number 23592733
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional basic dentistry
Research InstitutionOkayama University

Principal Investigator

SOGAWA Chiharu  岡山大学, 医歯(薬)学総合研究科, 助教 (10253022)

Co-Investigator(Kenkyū-buntansha) KITAYAMA Shigeo  岡山大学, 大学院医歯薬学総合研究科, 教授 (80177873)
SOGAWA Norio  岡山大学, 大学院医歯薬学総合研究科, 准教 (30236153)
MORITA Katsuya  広島文化学園大学, 看護学部看護学科, 教授 (10116684)
Project Period (FY) 2011 – 2013
Keywords神経因性疼痛 / トランスポーター / モノアミン / 抗うつ薬 / GABA
Research Abstract

Neuropathic pain is defined with for a chronic or persistent pain to be generated by a pathophysiological alteration on the peripheral and/or central nervous system (CNS). Antidepressants are known as the inhibitors of monoamine neurotransmitter transporters (MATs) are therapeutically useful ligands for the treatment of neuropathic pain. However, they do not sometimes provide enough effects. We focused the change of MATs expression level in the CNS after the onset of the neuropathic pain. In this study, MATs mRNA level decreased in the brain stem after onset of the pain in limited neuropathic pain model. We suggested that the change of MAT expression in the CNS associated with therapeutic efficacy of antidepressants for the neuropathic pain.

  • Research Products

    (14 results)

All 2014 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (7 results) Book (2 results)

  • [Journal Article] Protective effect of cepharanthin on cisplatin-induced renal toxicity through metallothionein expression2013

    • Author(s)
      Sogawa, N., Hazehara, Y., Kunitomo, K. Morita, Y., Bupsang, Y., Ohyama, K., Sogawa, C. and Kitayama, S
    • Journal Title

      Life Sci

      Volume: 92 Pages: 727-732

    • DOI

      10.1016/j.lfs.2013.01.031

    • Peer Reviewed
  • [Journal Article] Age-dependent changes in the susceptibility to thiopental anesthesia in mice : analysis of the relationship to the functional expression of GABA transporter2012

    • Author(s)
      Sogawa, N., Hazehara, Y., Kunitomo, K. Morita, Y., Bupsang, Y., Ohyama, K., Sogawa, C. and Kitayama, S
    • Journal Title

      Pharmaol. Biochem. Behav

      Volume: 103 Pages: 267-272

    • DOI

      10.1016/j.pbb.2012.08.027

    • Peer Reviewed
  • [Journal Article] Inhibitory action of antidepressants on mouse betaine/GABA Transporter (BGT1) heterologously expressed in cell cultures2012

    • Author(s)
      Gerile, Sogawa, C., Ohyama, K., Masuko, T., Kusama, T., Morita, K., Sogawa, N. and Kitayama, S
    • Journal Title

      Int. J. Mol. Sci

      Volume: 13 Pages: 2578-89

    • DOI

      10.3390/ijms13032578

    • Peer Reviewed
  • [Journal Article]2011

    • Author(s)
      Sogawa, C., Sogawa, N., Ohyama, K., Kikura-Hanajiri, R., Goda, Y., Sora, I. and Kitayama, S
    • Journal Title

      Curr Neuropharmacol

      Volume: 9(1) Pages: 58-62

    • DOI

      10.2174/157015911795017425

    • Peer Reviewed
  • [Journal Article] Antiallodynic action of 1-(3-(9H-Carbazol-9-yl)-1-propyl)-4-(2-methyo xyphenyl)-4-piperidinol (NNC05-2090), a betaine/GABA transporter inhibitor

    • Author(s)
      Jinzenji, A., Sogawa, C., Miyawaki, T., Wen, X., Yi, D., Ohyama, K., Kitayama, S., Sogawa, N., and Morita, K
    • Journal Title

      J. Pharmacol., Sci

      Volume: in press

    • Peer Reviewed
  • [Presentation] Wen, X., Sogawa, C., Ohyama, K., Jinzenji, A., Miyawaki, T., and Sogawa, N.: Coexpression of H3R decrease NET uptake activity and membrane expression in CHO cells stably express NET.第87回日本薬理学会年会、2014年3月21日、仙台。2014

    • Author(s)
      Wen, X., Sogawa, C., Ohyama, K., Jinzenji, A., Miyawaki, T., and Sogawa, N
    • Organizer
      NET.第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2014-03-21
  • [Presentation] Regulation of noradrenaline transporter gene expression by nicotine. Neuroscience 2013 Annual Meeting2013

    • Author(s)
      Sogawa,N., Sogawa, C., Ohyama, K., Wen, X., Yi, D. and Kitayama, S
    • Organizer
      Neuroscience 2013 Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2013-11-10
  • [Presentation] Anti-allodynic action of NNC 05-2090, a betaine/GABA transporter inhibitor2013

    • Author(s)
      Jinzenji, A., Sogawa, C., Miyawaki, T., Morita, K., Kitayama, S. and Sogawa, N
    • Organizer
      Neuroscience 2013 Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2013-11-09
  • [Presentation] 新規障害性疼痛に対するGABAトランスポーター阻害薬の効果2013

    • Author(s)
      秦泉寺紋子、十川千春、宮脇卓也、森田克也、十川紀夫、北山滋雄
    • Organizer
      第55回歯科基礎医学会学術大会
    • Place of Presentation
      岡山
    • Year and Date
      2013-09-21
  • [Presentation] Characterization of human noradrenaline transporter gene at 5'-flanking region2013

    • Author(s)
      Sogawa, C., Ohyama, K., Sogawa, N. and Kitayama, S
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-23
  • [Presentation] Post- transcriptional regulation of noradrenaline transporter by nicotine2013

    • Author(s)
      Ohyama, K., Sogawa, C., Wen, X., Morita, K., Sogawa, N. and Kitayama, S
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-23
  • [Presentation] ヒトノルアドレナリントランスポーター遺伝子5'プロモーター領域の解析2012

    • Author(s)
      北山滋雄、十川千春、大山和美、十川紀夫
    • Organizer
      第122回日本薬理学会近畿部会
    • Place of Presentation
      豊中
    • Year and Date
      2012-11-16
  • [Book] Site-directed Mutagenesis for the Identification of Ligand-binding Sites on Na+/Cl--dependent Neurotransmitter Transporters. Protein Purification and Analysis III - Methods and Applications2014

    • Author(s)
      Sogawa, C., Sogawa, N. and Kitayama, S.
    • Publisher
      (ISBN:=iConcept Press)
    • URL

      http://www.iconceptpress.com/books/protein-purification-and-analysis-iii--methods-and-applications/

  • [Book] Immunocytochemical approaches to the identification of membrane topology of the Na + /Cl - -dependent neurotransmitter transporters. Applications of immunocytochemistry2012

    • Author(s)
      Sogawa, C., Sogawa, N. and Kitayama, S
    • Total Pages
      117-134
    • Publisher
      INTECH

URL: 

Published: 2015-07-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi