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2013 Fiscal Year Final Research Report

Protein stabilization for TMEM16E

Research Project

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Project/Area Number 23592734
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional basic dentistry
Research InstitutionHiroshima University

Principal Investigator

KEI Tobiume  広島大学, 医歯薬保健学研究院, 准教授 (40350037)

Co-Investigator(Kenkyū-buntansha) MIZUTA Kuniko  広島大学, 医歯薬保健学研究院, 助教 (40432679)
Co-Investigator(Renkei-kenkyūsha) KAMATA Nobuyuki  広島大学, 医歯薬保健学研究院, 教授 (70242211)
Project Period (FY) 2011 – 2013
KeywordsTMEM16E / GDD1 / LGMD2L / Anoctamin
Research Abstract

We identified TMEM16E has a constitutive susceptibility to proteasome-dependent degradation, which was compromized by PI3K inhibitors or addition of a chemical chaperon in vitro.Since TMEM16E gains protein stability in skeltal muscle tissue,our results suggested tissue-specific environments (e.g., energy metabolism and molecular chaperon) may support stabilization of TMEM16E.

  • Research Products

    (8 results)

All 2014 2013 2012 2011

All Journal Article (8 results) (of which Peer Reviewed: 7 results)

  • [Journal Article] TMEM16E (GDD1) exhibits protein instability and distinct characteristics in chloride channel/pore forming ability2014

    • Author(s)
      Tran TT, Tobiume K, Hirono C, Fujimoto S, Mizuta K, Kubozono K, Inoue H, Itakura M, Sugita M, Kamata N
    • Journal Title

      J Cell Physiol

      Volume: 229(2) Pages: 181-90

    • DOI

      10.1002/jcp.24431

    • Peer Reviewed
  • [Journal Article] Autocrine galectin-1 promotes collective cell migration of squamous cell carcinoma cells through up-regulation of distinct integrins2013

    • Author(s)
      Rizqiawan A, Tobiume K, Okui G, Yamamoto K, Shigeishi H, Ono S, Shimasue H, Takechi M, Higashikawa K, Kamata N
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 441(4) Pages: 904-10

    • DOI

      10.1016/j.bbrc.2013.10.152

    • Peer Reviewed
  • [Journal Article] AKT primes snail-induced EMT concomitantly with the collective migration of squamous cell carcinoma cells2013

    • Author(s)
      Okui G, Tobiume K, Rizqiawan A, Yamamoto K, Shigeishi H, Ono S, Higashikawa K, Kamata N
    • Journal Title

      J Cell Biochem

      Volume: 114(9) Pages: 2039-49

    • DOI

      10.1002/jcb.24545

    • Peer Reviewed
  • [Journal Article] Interleukin-8 and CXCL10 expression in oral keratinocytes and fibroblasts via Toll-like receptors2013

    • Author(s)
      Fukui A, Ohta K, Nishi H, Shigeishi H, Tobiume K, Takechi M, Kamata N
    • Journal Title

      Microbiol Immunol

      Volume: 57(3) Pages: 198-206

    • DOI

      10.1111/1348-0421.12022

    • Peer Reviewed
  • [Journal Article] Snail promotes Cyr61 secretion to prime collective cell migration and form invasive tumor nests in squamous cell carcinoma2013

    • Author(s)
      Tanaka F, Rizqiawan A, Higashikawa K, Tobiume K, Okui G, Shigeishi H, Ono S, Shimasue H, Kamata N
    • Journal Title

      Cancer Lett

      Volume: 329(2) Pages: 243-52

    • DOI

      10.1016/j.canlet.2012.11.023

    • Peer Reviewed
  • [Journal Article] Overexpression of receptor for hyaluronan-mediated motility (RHAMM) in MC3T3-E1 cells induces proliferation and differentiation through phosphorylation of ERK1/22012

    • Author(s)
      Hatano H, Shigeishi H, Kudo Y, Higashikawa K, Tobiume K, Takata T, Kamata N
    • Journal Title

      J Bone Miner Metab

      Volume: 30(3) Pages: 293-303

    • DOI

      10.1007/s00774-011-0318-0

    • Peer Reviewed
  • [Journal Article] Blocking of sodium and potassium ion-dependent adenosine triphosphatase-al with ouabain and vanadate suppresses cell-cell fusion during RANKL-mediated osteoclastogenesis2011

    • Author(s)
      Makihira S, Nikawa H, Kajiya M, Kawai T, Mine Y, Kosaka E, Silva MJ, Tobiume K, Terada Y
    • Journal Title

      Eur J Pharmacol

      Volume: 670(2-3) Pages: 409-18

    • DOI

      10.1016/j.ejphar.2011.08.044

    • Peer Reviewed
  • [Journal Article] PGE_2 targets squamous cell carcinoma cell with the activated epidermal growth factor receptor family for survival against 5-fluorouracil through NR4A2 induction2011

    • Author(s)
      Shigeishi H, Higashikawa K, Hatano H, Okui G, Tanaka F, Tran TT, Rizqiawan A, Ono S, Tobiume K, Kamata N
    • Journal Title

      Cancer Lett

      Volume: 307(2) Pages: 227-36

    • DOI

      10.1016/j.canlet.2011.04.008

URL: 

Published: 2015-07-16  

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