2013 Fiscal Year Final Research Report
Characterization of LPS-induced hyper OPN osteoblasts
| Project/Area Number |
23592739
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
BANDOW Kenjiro 鹿児島大学, 医歯(薬)学総合研究科, 助教 (50347093)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUGUCHI Tetsuya 鹿児島大学, 医歯学総合研究科, 教授 (10303629)
OHNISHI Tomokazu 鹿児島大学, 医歯学総合研究科, 准教授 (30244247)
KUSUYAMA Joji 鹿児島大学, 医歯学総合研究科, 助教 (70596105)
KAKIMOTO Kyoko 鹿児島大学, 医歯学総合研究科, 助教 (40274849)
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| Project Period (FY) |
2011 – 2013
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| Keywords | OPN / osteoblast / LPS / Lmw-ptp / FAK / elaidic acid |
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| Research Abstract |
LPS-induced hyper OPN osteoblasts have an ability of osteoblastic differentiation and respond to mechanical stress less than low OPN cells. Lmw-ptp is up-regulated in hyper OPN osteoblast and decreases phosphorylation of FAK induced by mechanical stress. Though, it is unclear how OPN interacts with Lmw-ptp and FAK. Hyper OPN osteoblasts may be an intriguing target to develop therapeutic drugs against inflammatory bone diseases.
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Research Products
(9 results)
