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2013 Fiscal Year Final Research Report

Investigation on the molecular mechanism of aquaporin 5 distribution in salivary glands of Sjogren's syndrome model mice

Research Project

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Project/Area Number 23592781
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionThe Nippon Dental University

Principal Investigator

TOMOKO NASHIDA  日本歯科大学, 新潟生命歯学部, 准教授 (10133464)

Co-Investigator(Kenkyū-buntansha) IMAI Akane  日本歯科大学, 新潟生命歯学部, 准教授 (60180080)
YOSHIE Sumio  日本歯科大学, 新潟生命歯学部, 教授 (30095278)
SHIMOMURA Hiromi  日本歯科大学, 新潟生命歯学部, 教授 (40139259)
Co-Investigator(Renkei-kenkyūsha) HAGA Maiko (TSUJIMURA Maiko)  日本歯科大学, 新潟生命歯学部, 講師 (60535219)
SATO Ritsuko  日本歯科大学, 新潟短期大学, 准教授 (50178787)
Project Period (FY) 2011 – 2013
Keywordsアクアポリン / シェーグレン症候群 / マウス / 耳下腺
Research Abstract

1. The protein which co-localizes with aquaporin 5 was determined. Localization of these proteins was changed in the diabetic NOD mice. 2. Three spots of aquaporin 5 with different isoelectric points were determined.The main spot in the control mouse was detected at pI 6.0, and that in the diabetic NOD mouse was at pI 8.8 which coincides with the isoelectric point of aquaporin 5 without phosphorylation. This indicated that the phosphorylation level of aquaporin 5 was lower in the diabetic NOD mouse.

  • Research Products

    (29 results)

All 2013 2012 2011

All Journal Article (8 results) Presentation (21 results)

  • [Journal Article] Characterization of cysteine string protein in rat parotid acinar cells2013

    • Author(s)
      Shimomura H, Imai A, Nashida T
    • Journal Title

      Arch Biochem Biophys

      Volume: 538(1) Pages: 1-5

    • DOI

      10.1016/j.abb.2013.08.001

  • [Journal Article] MADD/DENN/Rab3GEP functions as a guanine nucleotide exchange factor for Rab27 during granule exocytosis of rat parotid acinar cells2013

    • Author(s)
      Imai A, Ishida M, Fukuda M, Nashida T, Shimomura H
    • Journal Title

      Arch Biochem Biophys

      Volume: 536(1) Pages: 31-7

    • DOI

      10.1016/j.abb.2013.05.002

  • [Journal Article] Atrophy of myoepithelial cells in parotid glands of diabetic mice; detection using skeletal muscle actin, a novel marker2013

    • Author(s)
      Nashida T, Yoshie S, Haga-Tsujimura M, Imai A, Shimomura H
    • Journal Title

      FEBS Open Bio

      Volume: 3 Pages: 130-134

    • DOI

      10.1016/j.fob.2013.01.009

  • [Journal Article] Antigen-presenting cells in parotid glands contain cystatin D originating from acinar cells2013

    • Author(s)
      Nashida T, Sato R, Haga-Tsujimura M, Yoshie S, Yoshimura K, Imai A, Shimomura H
    • Journal Title

      Arch Biochem Biophy

      Volume: 530 Pages: 32-39

    • DOI

      10.1016/j.abb.2012.12.009

  • [Journal Article] Chitinase expression in parotid glands of non-obese diabetic mice2012

    • Author(s)
      Fukushima T, Nashida T, Haga-Tsujimura M, Mataga I
    • Journal Title

      Oral Dis

      Volume: 18(5) Pages: 506-12

  • [Journal Article] Exocyst subunits are involved in isoproterenol-induced amylase release from rat parotid acinar cells2012

    • Author(s)
      Imai A,Yoshie S,Haga-Tsujimura M,Nashida T, Shimomura H
    • Journal Title

      Eur J Oral Sci

      Volume: 120 Pages: 123–131

    • DOI

      10.1111/j.1600-0722.2012.00952

  • [Journal Article] EPI64 protein functions as a physiological GTPase-activating protein for Rab27 protein and regulates amylase release in rat parotid acinar cells2011

    • Author(s)
      Imai A, Yoshie S, Ishibashi K, Haga-Tsujimura M, Nashida T, Shimomura H, Fukuda M
    • Journal Title

      J Biol Chem

      Volume: 286(39) Pages: 33854-62

    • DOI

      10.1074/jbc.M111.281394

  • [Journal Article] Evidence for amylase release by cyclin-dependent kinase 5 in the rat parotid2011

    • Author(s)
      Shimomura H, Imai A, Nashida T
    • Journal Title

      Arch Biochem Biophys

      Volume: 507 Pages: 310–314

    • DOI

      10.1016/j.abb.2010.12.025

  • [Presentation] NODマウス耳下腺腺房細胞における抗菌性タンパク質の発現2013

    • Author(s)
      梨田智子,吉江紀夫,佐藤律子,今井あかね,下村浩巳
    • Organizer
      第55回日本歯科基礎医学会学術大会
    • Place of Presentation
      岡山
    • Year and Date
      20130920-22
  • [Presentation] 小児における齲蝕と遺伝的要因についての検討2013

    • Author(s)
      下村-黒木淳子,竜佑宗,梨田智子
    • Organizer
      第55回日本歯科基礎医学会学術大会
    • Place of Presentation
      岡山
    • Year and Date
      20130920-22
  • [Presentation] 唾液ヒスタチンmRNAレベルと口腔環境衛生との相関性2013

    • Author(s)
      佐藤律子,梨田智子,三上正人,今井あかね
    • Organizer
      第55回日本歯科基礎医学会学術大会
    • Place of Presentation
      岡山
    • Year and Date
      20130920-22
  • [Presentation] Antibacterial proteins in parotid acinar cells of non-obese diabetic mouse2013

    • Author(s)
      Nashida T, Yoshie S, Mizuhashi F, Sato R, Imai A, and Shimomura H
    • Organizer
      2nd Meeting of IADR–Asia Pacific Region
    • Place of Presentation
      バンコック(タイ)
    • Year and Date
      20130821-23
  • [Presentation] Relation of mRNA level histatine2013

    • Author(s)
      Sato R, Nashida T, Tsutida S, Susuga M, Kikuchi H, Harada S, Sato A, Miyazaki A, Takahashi A, Imai A, Suda T and Shimomura H
    • Organizer
      2nd Meeting of IADR–Asia Pacific Region
    • Place of Presentation
      バンコック(タイ)
    • Year and Date
      20130821-23
  • [Presentation] Identification and Characterization of CSP in parotid acinar cells.2013

    • Author(s)
      Shimomura H, Imai A, Nashida T
    • Organizer
      91th General Session & Exhibition of the IADR
    • Place of Presentation
      シアトル(USA)
    • Year and Date
      20130320-23
  • [Presentation] Role of Rab27-GEF in parotid acinar cell exocytosis2013

    • Author(s)
      Imai A, Ishida M, Fukuda M, Nashida T, Shimomura H
    • Organizer
      91th General Session & Exhibition of the IADR
    • Place of Presentation
      シアトル(USA)
    • Year and Date
      20130320-23
  • [Presentation] ラット耳下腺腺房細胞の開口分泌時におけるRab27のGDP/GTP交感サイクル2013

    • Author(s)
      今井あかね,石田森衛,吉江紀夫,辻村麻衣子,佐藤律子,梨田智子,福田光則
    • Organizer
      第58回日本唾液腺学会
    • Place of Presentation
      東京
    • Year and Date
      2013-12-14
  • [Presentation] DENN/MADD/Rab3GEPは耳下腺腺房細胞においてRab27のGDP/GTP交換因( GEF)として機能する2012

    • Author(s)
      今井あかね,石田森衛,福田光則,梨田智子,下村浩巳
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      20121214-16
  • [Presentation] 耳下腺腺房細胞の開口分泌におけるRab27のグアニンヌクレオチド交換因子(GEF)関与2012

    • Author(s)
      今井あかね,梨田智子,下村浩巳
    • Organizer
      第54回日本歯科基礎医学会大会
    • Place of Presentation
      郡山
    • Year and Date
      20120914-16
  • [Presentation] マウス耳下腺筋上皮細胞における骨格筋アクチンの発現2012

    • Author(s)
      梨田智子,吉江紀夫,羽下-辻村麻衣子,今井あかね,下村浩巳
    • Organizer
      第54回日本歯科基礎医学会大会
    • Place of Presentation
      郡山
    • Year and Date
      20120914-16
  • [Presentation] lincRNA in parotid acinar cells of non-obese diabetic mouse2012

    • Author(s)
      Nashida T, Imai A, Shimomura H
    • Organizer
      90th General Session & Exhibition of the IADR
    • Place of Presentation
      フォスドイグアス(ブラジル)
    • Year and Date
      20120621-23
  • [Presentation] Role of exocyst subunits in parotid acinar cells2012

    • Author(s)
      Imai A, Yoshie S, Haga-Tsujimura M, Nashida T, Shimomura H
    • Organizer
      90th General Session & Exhibition of the IADR
    • Place of Presentation
      フォスドイグアス(ブラジル)
    • Year and Date
      20120621-23
  • [Presentation] ラット耳下腺と腎臓におけるシスタチン10の発現2011

    • Author(s)
      佐藤律子,梨田智子,吉江紀夫,羽下麻衣子,今井あかね,下村浩巳
    • Organizer
      第53回日本歯科基礎医学会大会
    • Place of Presentation
      岐阜
    • Year and Date
      20110925-27
  • [Presentation] 耳下腺腺房細胞におけるRab27とRab35の働き2011

    • Author(s)
      今井あかね,吉江紀夫,羽下-辻村麻衣子,梨田智子,下村浩巳
    • Organizer
      第53回日本歯科基礎医学会大会
    • Place of Presentation
      岐阜
    • Year and Date
      20110925-27
  • [Presentation] Cystatin 10のラットにおける発現と動態2011

    • Author(s)
      梨田智子,佐藤律子,吉江紀夫,羽下麻衣子,今井あかね,下村浩巳
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      20110922-24
  • [Presentation] 耳下腺腺房細胞EPI64はRab27-GTPase- activating protein (Rab27-GAP)として開口分泌にかかわっている2011

    • Author(s)
      今井あかね,吉江紀夫,石橋弘太郎,福田光則,羽下麻衣子,梨田智子,下村浩巳
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      20110922-24
  • [Presentation] Expression of aquaporins in parotid glands of NOD mouse2011

    • Author(s)
      Nashida T, Yoshie S, Haga M, Imai A, Shimomura H
    • Organizer
      9th European Symposium on Saliva
    • Place of Presentation
      エグモンドアアンジー(オランダ)
    • Year and Date
      20110523-25
  • [Presentation] Phosphorylation of Munc18c by CDK5 evokes exocytosis in rat parotid2011

    • Author(s)
      Shimomura H, Imai A, Nashida T
    • Organizer
      9th European Symposium on Saliva
    • Place of Presentation
      エグモンドアアンジー(オランダ)
    • Year and Date
      20110523-25
  • [Presentation] Cystatin 10 in rat parotid and kidney2011

    • Author(s)
      Sato R, Nashida T, Imai A, Shimomura H, Haga M, Yoshie S
    • Organizer
      9th European Symposium on Saliva
    • Place of Presentation
      エグモンドアアンジー(オランダ)
    • Year and Date
      20110523-25
  • [Presentation] Cystatin Dのラット耳下腺における発現と動態2011

    • Author(s)
      佐藤律子,梨田智子,羽下麻衣子,吉江紀夫,今井あかね,下村浩巳
    • Organizer
      第56回日本唾液腺学会
    • Place of Presentation
      東京
    • Year and Date
      2011-12-03

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Published: 2015-07-16  

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