2013 Fiscal Year Final Research Report
Development of dual induction therapy for the regulation of chronic inflammation and hard tissue formation of dental pulp and periapical tissues
| Project/Area Number |
23592803
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHIHARA Tatsuji 九州歯科大学, 歯学部, 教授 (80192251)
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| Co-Investigator(Renkei-kenkyūsha) |
WASHIO Ayako 九州歯科大学, 歯学部, 助教 (10582786)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 歯髄 / 根尖歯周組織 / 象牙芽細胞 / 骨芽細胞 / 再生医療 |
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| Research Abstract |
To develop dual induction therapy for the regulation of chronic inflammation and hard tissue formation of dental pulp and periapical tissues, we focused on effects of newly developed cement on several cells, effects of steroid coactivator MTI-II on osteoblasts, effects of PRP and BMP-2 on odontoblasts, and effects of ameloblastin on epithelial cells. We found that the biocompatibility of newly developed cement, effects of BMP-2 on odontoblast differentiation, the suppression of epithelial cell proliferation by ameloblastin, the regulation of inflammatory responses of osteoblasts by MTI-II, and the induction of odontoblast differentiation related molecules by PRP.
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