2013 Fiscal Year Final Research Report
Development of new bone filling materials using Sr-containing bioactive glasses
| Project/Area Number |
23592821
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
IZUMI Toshio 福岡歯科大学, 歯学部, 准教授 (40248547)
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| Co-Investigator(Kenkyū-buntansha) |
ANAN Hisashi 福岡歯科大学, 口腔歯学部, 教授 (80158732)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUYA Shigeki 福岡歯科大学, 口腔歯学部, 教授 (00108755)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 生体活性ガラス / ストロンチウム / ポリグルタミン酸 / 骨補填材 |
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| Research Abstract |
Strontium (Sr) that has been proved to promote bone formation in vivo is used as an anti-osteoporotic oral drug. The bioactive glass can bond chemically to bone through formation of bone-like hydroxyapatite layer on its surface, and is used as a bone substitute material. We prepared trial products of Sr-containing bioactive glass particles, and it was suggested that they could promote bone regeneration in rat calvarial defects. There may be an association with the controlled release of Sr to the bone tissue, which occured by dissolution of the glass particles.
Hardened cement pastes were made by mixing acid and the Sr-containing glass particles in order to fill densely the rat calvarial defects. When polyglutamic acid was used, a cement paste was easy to flow out of the defects, but it was suggested that the paste should promote formation of new bone.
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