2013 Fiscal Year Final Research Report
The study of cementum regeneration in epithelial-mesenchymal interaction
| Project/Area Number |
23592880
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
SHIMONISHI Mitsuru 東北大学, 歯学研究科(研究院), 大学院非常勤講師 (40302153)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 再生歯学 / セメント質 / マラッセの上皮遺残 |
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| Research Abstract |
Both the epithelial cells of Malassez and periodontal ligament fibroblasts were co-cultured in the same dish. The interactions between the epithelial cells of Malassez and periodontal ligament fibroblastscurrent induceed the expression of amelogenin, ameloblastin, MMP-20 and KLK 4 in the epithelial cells of Malassez.
We also showed that the epithelial cells of Malassez which incorporated BrdU expressed Bax strongly in co-cultured cells, suggesting that the epithelial-mesenchymal interactions enhance cell turnover in the epithelial cells of Malassez.
These results indicate that epithelial-mesenchymal interactions may induce cell turnover and cellular cementum formationin in the epithelial cells of the rests of Malassez.
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