2013 Fiscal Year Final Research Report
Development of resin contained Ag-doped bioglass that inhibit MMP activity of dentin
| Project/Area Number |
23592894
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ENDO Kazuhiko 北海道医療大学, 歯学部, 教授 (70168821)
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| Project Period (FY) |
2011 – 2013
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| Keywords | MMP / バイオガラス / 劣化 / レジン接着 |
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| Research Abstract |
We evaluated the effects of a Ag-doped bioglass on inhibition of MMP and cytotoxicity to cells (RAW264). Ag-doped bioglass with 3% Ag2O inhibited the activity of MMP-2 and MMP-9 derived from dentin. However, this bioglass also showed cytotoxic effects. These findings may be attributed to the release of ions from bioglass. Further studies are required to optimize the bioglass composition for controlled release of ions to increase the inhibition effect of MMP activity and decrease the cytotoxicity.
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