2013 Fiscal Year Final Research Report
The development of the cementum / periodontal membrane reproduction type implant with induced pluripotent stem cells derived from oral mucosa
| Project/Area Number |
23592905
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATOMURA Kazuhito 鶴見大学, 歯学部, 教授 (80243715)
HAYAKAWA Toru 鶴見大学, 歯学部, 教授 (40172994)
SATO Toru 鶴見大学, 歯学部, 講師 (30170765)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 再生歯学 / 口腔粘膜由来iPS細胞 |
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| Research Abstract |
Under existence of a lining-of-the-mouth origin iPS cell, Emdogain, and Matarigel, in co-culture with HAT-7 cell, The cell growth of an iPS cell stock, altered morphology, And existence of the Pax inducing factor in the rat odontogenic epithelial cell (HAT-7) surface and the inducible activity of Pax9 in the rat odontogenic epithelial cell (HAT-7) surface were accepted by the revelation and co-culture of Msx1, Pax9, and Lhx6 which are the transcription factors revealed in a dental generating process.
Although the cell growth factor contained in Emdogain, Matigel, and GFR Matarigel, was comprehensively analyzed using the antibody array and the Bio-Plex suspension array system, it did not result in identification of a cell growth factor.
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