2015 Fiscal Year Final Research Report
Bone augmentation of jaw and alveolus bone with coral block in preprosthetic surgery.
| Project/Area Number |
23592909
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Osaka Dental University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2016-03-31
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| Keywords | 足場材料 / 骨再生 / 骨増生 / サンゴ / 新生骨 / 補綴前処置 |
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| Outline of Final Research Achievements |
Inside the coral were innumerable tubular structures 100-300 μm in diameter that communicated with the outside, connected to neighboring ducts through pores. The surface of the skeleton was covered with 10-20 μm protrusions, on the surface of which further rounded projections of 6-200 nm were observed. The calcium of coral was released in acid solution, and calcium irons in the alkaline solution were deposited on the surface coral particles. In vitro, formation of capillaries was seen around coral particles. In vivo, at bone defects of dogs and on the skull of rats, multinucleated giant cells were observed in contact with the implanted coral, and bone augmentation was seen together with newly formed bone bordered by osteoblasts in the inner cavities of the coral block. After 12 months, coral block were disappeared and replaced with newly formed bone and bone marrow.
The above suggests that coral blocks are promising as a bioabsorpable scaffolding material for bone augmentation.
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| Free Research Field |
口腔病理
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