Possibility of limited resection following preoperative therapy for squamous cell carcinoma of the tongue based on real-time tissue elastography

2013 Fiscal Year Final Research Report

• Project/Area Number: 23592914
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: HARADA Hiroyuki 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (40343149)
• Co-Investigator(Renkei-kenkyūsha): OMURA Ken 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (10334434)
• Project Period (FY): 2011 – 2013
• Keywords: 舌扁平上皮癌 / 組織弾性イメージング / 縮小手術

Research Abstract

Preservation of function is an important issue in the treatment of oral cancers. With recent advances in anticancer agents and radiation therapy, many patients are known to obtain a high antitumor effect. Using real-time tissue elastography, the elasticity of squamous cell carcinoma of the tongue was measured, and the elasticity of scar portions was quantified in cases when preoperative therapy was performed.
This result was as expected and is a finding that shows that the portion of cancer tissue lost with preoperative therapy had lower elasticity than cancer and higher elasticity than normal tissue. If a cutoff value for tumor tissue and scar tissue can be established in the future, the possibility of limited surgery can probably be expanded.

Research Products

• [Journal Article] Multicenter phase II trial of preoperative chemoradiotherapy with S-1 for locally advanced oral squamous cell carcinoma (2013)
  • Author(s): Harada H, Omura K, Tomioka H, Nakayama H, Hiraki A, Shinohara M, Yoshihama Y, Shintani S.
  • Journal Title: Cancer Chemother Pharmacol Volume: 71(4) Pages: 1059-1064
  • Peer Reviewed
• [Journal Article] Cervical lymph node metastasis from early-stage squamous cell carcinoma of the oral tongue (2013)
  • Author(s): Yuasa-Nakagawa K, Shibuya H, Yoshimura R, Miura M, Watanabe H, Kishimoto S, Omura K.
  • Journal Title: Acta Otolaryngol Volume: 133(5) Pages: 544-551
  • Peer Reviewed
• [Journal Article] Evaluation of metastatic cervical lymph nodes in patients with oral squamous cell carcinoma using 18F-FDG PET-CT scans and histopathologic correlation (2012)
  • Author(s): Mochizuki Y, Omura K, Nakamura S, Kayamori K, Harada H, Shibuya H.
  • Journal Title: J Surg Rad Volume: 3(4) Pages: 210-215
  • Peer Reviewed
• [Journal Article] Preoperative predictive model of cervical lymph node metastasis combining fluorine-18 fluorodeoxyglucose positron-emission tomography/computerized tomography findings and clinical factors in patients with oral or oropharyngeal squamous cell carcinoma (2012)
  • Author(s): Mochizuki Y, Omura K, Nakamura S, Harada H, Shibuya H, Kurabayashi T.
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Volume: 113(2) Pages: 274-282
  • Peer Reviewed
• [Journal Article] Cementoblastoma arising in the maxilla of an 8-year-old boy : a case report (2011)
  • Author(s): Harada H, Omura K, Mogi S, Okada N.
  • Journal Title: Int J Dent Volume: 2011 Pages: 384578
  • Peer Reviewed
• [Journal Article] 当科受診前に外科処置が行われた歯肉癌症例の検討 (2011)
  • Author(s): 富岡寛文, 小村健, 原田浩之, 生田稔
  • Journal Title: 頭頸部癌 Volume: 37(1) Pages: 18-23
  • Peer Reviewed
• [Presentation] シンポジウム「口腔外科治療の最前線」口底扁平上皮癌の臨床病理学的検討 (2013)
  • Author(s): 原田浩之, 小村健, 島本裕彰
  • Organizer: 第51回日本癌治療学会総会
  • Place of Presentation: 京都
  • Year and Date: 20131024-26
• [Presentation] 口腔扁平上皮癌における選択的頸部郭清術 (2013)
  • Author(s): 原田浩之, 小村健, 島本裕彰
  • Organizer: 第37回日本頭頸部癌学会
  • Place of Presentation: 東京
  • Year and Date: 20130613-14
• [Presentation] Clinico-pathological study on occult cervical lymph node metastasis in oral tongue carcinoma (2013)
  • Author(s): Harada H, Omura K, Nakajima Y, Shimamoto H, Tomioka H, Tanaka K, Hirai H.
  • Organizer: 4th World Congress of the International Academy of Oral Oncology
  • Place of Presentation: Rohdes Island, Greece
  • Year and Date: 20130515-18
• [Presentation] Bone invasion relate to cervical lymph node metastasis in squamous cell carcinoma of lower gingiva (2013)
  • Author(s): Tomioka H, Omura K, Kugimoto T, Hirai H, Mochizuki Y, Tanaka K, Shimamoto H, Nakajima Y, Harada H.
  • Organizer: 4th World Congress of the International Academy of Oral Oncology
  • Place of Presentation: Rohdes Island, Greece
  • Year and Date: 20130515-18
• [Presentation] 舌扁平上皮癌N0症例の頸部後発転移に関する臨床病理学的検討 (2012)
  • Author(s): 原田浩之, 小村健, 中島雄介, 島本裕彰, 富岡寛文, 田中香衣, 釘本琢磨, 大迫利光
  • Organizer: 第57回日本口腔外科学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 20121019-21
• [Presentation] 口底扁平上皮癌における原発巣再発の臨床的検討 (2012)
  • Author(s): 原田浩之, 小村健, 中島雄介, 島本裕彰, 富岡寛文, 田中香衣, 釘本琢磨, 大迫利光
  • Organizer: 第36回日本頭頸部癌学会
  • Place of Presentation: 松江市
  • Year and Date: 20120607-08
• [Presentation] 口底扁平上皮癌の臨床病理学的検討 (2011)
  • Author(s): 原田浩之, 小村健, 中島雄介,生田稔, 島本裕彰, 富岡寛文, 田中香衣, 金親あや乃, 釘本琢磨, 大迫利光
  • Organizer: 第35回日本頭頸部癌学会
  • Place of Presentation: 名古屋市
  • Year and Date: 20110609-10
• [Presentation] 口腔扁平上皮癌における術前TS-1・放射線同時併用療法の臨床第II相試験 (2011)
  • Author(s): 原田浩之, 小村健, 中山秀樹, 平木昭光, 篠原正徳, 吉濱泰斗
  • Organizer: 第29回日本口腔腫瘍学会総会
  • Place of Presentation: 熊本市
  • Year and Date: 20110127-28
• [Presentation] 口腔扁平上皮がん頸部リンパ節転移の術前診断における18FDG-PETの有用性の検討 (2011)
  • Author(s): 望月裕美, 中村伸, 小村健, 原田浩之, 中島雄介, 生田稔, 島本裕彰, 森田圭一, 富岡寛文,田中香衣,金親あや乃, 渋谷均
  • Organizer: 第29回日本口腔腫瘍学会総会
  • Place of Presentation: 熊本市
  • Year and Date: 20110127-28