2013 Fiscal Year Final Research Report
Verification of iPS cell induction efficiency and gene expression profile of human dental pulp cells
| Project/Area Number |
23592917
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Gifu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAGUCHI Tomoko 岐阜大学, 医学部附属病院, 医員 (30509815)
TAMAOKI Naritaka 岐阜大学, 医学系研究科, 助教 (40585303)
IIDA Kazuki 岐阜大学, 医学部附属病院, 助教 (30585237)
SHIBATA Toshiyuki 岐阜大学, 医学系研究科, 教授 (50226172)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ヒト歯髄細胞 / iPS細胞 |
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| Research Abstract |
Induction efficiency of iPS cells from human dental pulp cells was significantly higher in the root un-formative group compared with the root completed group. The results of the DNA microarray analysis of the root completed group and the root un-formative group, there was twenty-eight gene expression was observed amount of more than five times the average. We have clarified that the DLX4 can be a new factor in the iPS cell induction. Furthermore, the use of DLX4 was suggested to promote the efficiency of inducing iPS cells.
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[Journal Article] Hypoxia-enhanced derivation of iPSCs from human dental pulp cells2013
Author(s)
Iida K, Takeda-Kawaguchi T, Hada M, Yuriguchi M, Aoki H, Tamaoki N, Hatakeyama D, Kunisada,T, Shibata,T, Tezuka K.
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Journal Title
Journal of dental research
Volume: 92(10)
Pages: 905-10
Peer Reviewed
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