2014 Fiscal Year Final Research Report
Regulatory effects of redox-sensitive transcription factor activation by antioxidative phenol-related compounds.
| Project/Area Number |
23592939
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Meikai University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | 口腔外科学一般 |
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| Outline of Final Research Achievements |
We investigated the inhibitory effects of phenol related compounds; eugenol,bis-eugenol,honokiol、magnolol、p-cresol、p-cresol dimer、p-hydroxyanisole (pHA)、pHA dimer and tocopherols, and bioactive compounds; indol and melatonin on the redox-sensitive transcription factor activation stimulated with LPS or other stimulants in mammalian cells. Some of phenolic dimmers and melatonin inhibited a transcriptional activity of nuclear factor kappa B and also suppressed cyclooxygenase-2 expression. These observations suggested that inhibitory effects of these compounds on NF-κB activation and cox2 expression might be associated with their antioxidant activity. These antioxidant compounds may be applicable for preventing chronic inflammation and carcinogenesis.
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| Free Research Field |
医歯薬学
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