2013 Fiscal Year Final Research Report
Linkage study about HLA alleles of recurrent aphthous stomatitis
| Project/Area Number |
23592940
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATO Tsuyoshi 埼玉医科大学, 医学部, 講師 (60406494)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 慢性再発性アフタ / ＨＬＡ / 連鎖解析 |
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| Research Abstract |
We extracted the DNA of 27 families (98sumples), including patients with recurrent aphthous stomatitis patients. We did the nucleotide sequence level typing on HLA-A,-B,-Cw,-DRB1 locus. We performed linkage study on each locus. Linkage disequilibrium was observed as DRB1 locus and the entire HLA-Cw <P=0.01, P=0.03>.And It was suggested that HLA-Cw*0303 has a signifficant association with recurrent aphthous stomatitis.
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