2013 Fiscal Year Final Research Report

Functional analysis of melanocortin receptor agonists in bone metabolism and the possibility of clinical application for osteonecrosis of the jaw

Research Project

Project/Area Number	23592941
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Surgical dentistry
Research Institution	Saitama Medical University
Principal Investigator	SATO Tsuyoshi 埼玉医科大学, 医学部, 講師 (60406494)
Co-Investigator(Kenkyū-buntansha)	USUI Michihiko 九州歯科大学, 歯学部, 准教授 (10453630)
Co-Investigator(Renkei-kenkyūsha)	TAKEDA Shu 東京医科歯科大学, 医学部, 教授 (30376727)
Project Period (FY)	2011 – 2013
Keywords	ACTH / 骨 / VEGF
Research Abstract	We investigated whether adrenocorticotropic hormone(ACTH) affects bone directly. using ACTH receptor knockout mice, bone mineral density was significantly upregulated. Osteoblast differentiation was inhibited and osteoclast differentiation was promoted by ACTH stimulation. In ACTH receptor knockout mice,VEGF-D expression was upregulated. Although ACTH is effective for vascularlization, there is the possibility that ACTH may inhibit bonew formation.

(4 results)