The role of cyclooxygenase -2 on bone response after the placement of porous hydroxyapatite syntetic bone.

2014 Fiscal Year Final Research Report

• Project/Area Number: 23592946
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Tokyo Medical University
• Principal Investigator: HASEGAWA ON 東京医科大学, 医学部, 助教 (50424619)
• Co-Investigator(Kenkyū-buntansha): CHIKAZU Daichi 東京医科大学, 医学部, 教授 (30343122) ; ABUKAWA Harutsugi 東京医科大学, 医学部, 助教 (50453717) ; MATSUO Akira 東京医科大学, 医学部, 准教授 (70229417) ; NAKAI Takayuki 東京医科大学, 医学部, 助教 (70349471) ; SATOMI Takafumi 東京医科大学, 医学部, 准教授 (70276921)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: ハイドロキシアパタイト骨補填材 / COX-2ノックアウトマウス

Outline of Final Research Achievements

The aim of this study was to examine the role of cyclooxygenase(cox)-2 on bone response after the placement of porous hydroxyapatite synthetic bone, Radiological & Histopathological. Both radiological & histopathological study showed no significant difference between wildmice and knockout mice. Although new bone formation on porous hydroxyapatite was visible, there is no woven bone formation was observed in cox-2 knockout mice. Possibility that cox-2 involved in bone reaction around the porous hydroxyapatite synthetic bone has been highly suggested.

Free Research Field

医歯薬学