2013 Fiscal Year Final Research Report
Reguratiion for invasion of OSCC by reptin
| Project/Area Number |
23592952
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kinki University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 癌の浸潤・転移 / 上皮間葉移行 / レプチン / 扁平上皮癌 / 口腔癌 |
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| Research Abstract |
The degradation of extracellular matrix (ECM) is one of the most important processes in the invasion and metastasis of malignant tumor cells. Reptin gene, is known a component of the chromatin remodeling complex, is reported that repress the expression of the metastasis suppressor gene and hence repress the invasion and metastasis of malignant tumor cells. In this study, using two cell lines derived from human oral squamous cell carcinomas, OSC-19 and OSC-20, we demonstrated that knockdown of reptin gene promoted mobility, changed those cells shapes to spindle, and suppress the expression of E-cadherin, promoted the expression of N-cadherin. These phenomena is indicated that reptin regulate the invasiveness into the ECM with relation to EMT (epithelial-mesenchymal transition).
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