2013 Fiscal Year Final Research Report
A novel strategy against bone invasion of oral cancer
| Project/Area Number |
23592957
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | University of Toyama |
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Principal Investigator |
NOGUCHI Makoto 富山大学, 大学院医学薬学研究部(医学), 教授 (50208328)
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| Co-Investigator(Kenkyū-buntansha) |
ARAI Naoya 三重大学, 大学院医学系研究科, 教授 (80323723)
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| Research Collaborator |
TOMIHARA Kei 富山大学, 大学院医学薬学研究部, 講師 (70404738)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 口腔癌 |
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| Research Abstract |
Despite CD4+T cells have been demonstrated to play an important role for bone destruction in the microenvironment of inflammatory diseases, very little work has been done to demonstrate the contribution of these cell types to cancer bone invasion. In the present study, we investigated the mechanism of interaction between regulatory T cells (Tregs) and osteoclasts in a murine model of oral cancer to elucidate the role of Tregs in the bone invasion of oral cancer. Tregs were purified from the tumor of mouse oral cancer model and then cocultured with bone marrow cells. Secreted tartrate-resistant acid phosphatase (TRACP) 5b was determined as a marker of osteoclast number. Attenuation of osteoclast-derived TRACP5b was observed in the coculture of tumor derived Tregs and bone marrow cells, and this attenuation of TRACP5b was ameliorated by neutralization of cytotoxic T-lymphocyte-associated antigens-4 (CTLA-4).
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Research Products
(8 results)
