2013 Fiscal Year Final Research Report
Application of neamine as a new anticancer drug targeted angiogenin for oral cancer
| Project/Area Number |
23592961
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
KISHIMOTO Koji 岡山大学, 医歯(薬)学総合研究科, 助教 (40243480)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
IBARAGI Soichiro 岡山大学, 大学病院, 助教 (80549866)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YOSHIOKA Norie 岡山大学, 大学院医歯薬学総合研究科, 助教 (50362984)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | angiogenin / neamine / 血管新生 / 細胞増殖 / リボゾームRNA / 口腔癌 |
|---|
| Research Abstract |
An angiogenic protein, angiogenin undergoes nuclear translocation and stimulates ribosomal RNA transcription in both endothelial and cancer cells. Consequently, angiogenin has a dual effect on cancer progression by inducing both angiogenesis and cancer cell proliferation. Our results suggest that neamine, a blocker of nuclear translocation of angiogenin effectively inhibits oral cancer progression through inhibition of tumor angiogenesis. Neamine also directly inhibits proliferation of certain types of oral cancer cells. Therefore, neamine has potential as a lead compound for oral cancer therapy.
|
