2013 Fiscal Year Final Research Report
Significance as a therapeutic target and elucidation of EMT in a low oxygen environment of oral squamous cell carcinoma
| Project/Area Number |
23592968
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
ISHIDA Takayuki 鹿児島大学, 医学部・歯学部附属病院, 助教 (20404501)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAWAKI Akihiko 産業医科大学, 病院, 講師 (40200216)
HIJIOK Hiroshi 鹿児島大学, 医学部歯学部附属病院, 講師 (70305150)
IKEDA Ryuji 鹿児島大学, 医学部歯学部附属病院, 准教授 (50398278)
NAKAMURA Norifumi 鹿児島大学, 医学部医歯学総合研究科, 教授 (60217875)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 口腔癌 / 低酸素 / EMT / Notch |
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| Research Abstract |
We compared invasion and motility and expression of E-cadherin in oral cancer cell linescultured in a normal environment and low oxygen environment. They were increased in a low oxygen environment, but suppressed by the addition of Notch inhibitors. We examined the expression of Notch-related factors in the real time PCR, showed an enhanced expression of Notch signaling in a low-oxygen environment. These results suggested possibility that induce EMT in oral cancer cell lines via the Notch pathway by low oxygen environments, and might suggest Notch passway to be a therapeutic target for inhibiting metastasis of oral cancer.
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