An experimental study on the effects of platelet rich plasma on the wound healing of tooth extraction-related bone defects and tooth autotransplantation

2014 Fiscal Year Final Research Report

• Project/Area Number: 23592983
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Niigata University
• Principal Investigator: NIIMI Kanae 新潟大学, 医歯学総合病院, 助教 (20397136)
• Co-Investigator(Kenkyū-buntansha): YOSHIZAWA Michiko 新潟大学, 医歯学総合研究科, 講師 (60303137)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 多血小板血漿 / 歯の移植

Outline of Final Research Achievements

<Purpose>The objective of this study was to evaluate the effectiveness of PRP in inducing the healing of tooth extraction-related sockets for better prognosis of tooth transplantation. <Materials and Methods> All molars of rats were extracted, and bone defects were made. Blood was drawn from other rats, and PRP was prepared.The specimens werestained with hematoxylin and eosin. The sections were also studied　immuno-histochemically.<Results and Conclusions> PRP treatment induced the formation of a rich fibrin network and early inflammatory reactions in the experimental group, which may have led to the development of thick, vessel-rich granulation tissue. These results suggest that the growth factors secreted from granulation tissue may have stimulated wound healing in the experimental group. Consequently, the application of PRP may induce wound healing in tooth extraction-related bone defects.

Free Research Field

口腔外科