2013 Fiscal Year Final Research Report
The elucidation of role of motor neurons or pain pathways of the spinal cord in analgesia, muscle reluxation, and immobility as general anesthetic factors
| Project/Area Number |
23592992
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
IRIFUNE MASAHIRO 広島大学, 医歯薬保健学研究院(歯), 教授 (10176521)
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| Co-Investigator(Kenkyū-buntansha) |
MORITA Katsuya 広島文化学園大学, 看護学部, 教授 (10116684)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 全身麻酔要素 / 正向反射 / 鎮痛 / 不動化 / MK-801 / ハロペリドール / デクスメデトミジン / モルヒネ |
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| Research Abstract |
The role of substance P (SP) of the spinal cord in immobility as one of the general anesthetic factors was studied. Dexmedetomidine and morphine inhibit SP release from primary afferent neurons in the spinal cord. The selective N-methyl-D-aspartate (NMDA) channel blocker MK-801 is known to induce no loss of the righting reflex (LORR) and to stimulate catecholaminergic neurons in rodents, playing a crucial role in arousal. MK-801 in combination with a small dose of the dopamine (DA) receptor antagonist haloperidol dose-dependently produced LORR, but not immobility. Dexmedetomidine and morphine induced immobility in animals treated with MK-801 plus haloperidol, which then lost their righting reflex. These findings suggest that the immobility involves the inhibition of SP release in the spinal cord.
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[Journal Article] Selective blockade of N-methyl-D-aspartate channels in combination with dopamine receptor antagonism induces loss of the righting reflex in mice, but not immobility
Author(s)
Kikuchi, Nobuhito; Irifune, Masahiro; Shimizu, Yoshitaka; Yoshida, Keita; Morita, Katsuya; Kanematsu, Takashi; Morioka, Norimitsu; Nakata, Yoshihiro; Sakai, Norio
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Journal Title
Psychopharmacology
Volume: (in press)
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