Development of the high functional GBR membrane with osteoconduction and resorption by osteoclast

2013 Fiscal Year Final Research Report

• Project/Area Number: 23592993
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hiroshima University
• Principal Investigator: TAKECHI Masaaki 広島大学, 医歯薬保健学研究院, 准教授 (00304535)
• Co-Investigator(Kenkyū-buntansha): KAMATA Nobuyuki 広島大学, 医歯薬保健学研究院, 教授 (70242211) ; OHTA Kouji 広島大学, 病院, 助教 (20335681) ; NAKAGAWA Takayuki 広島大学, 病院, 病院助教 (30456230)
• Co-Investigator(Renkei-kenkyūsha): ISHIKAWA Kunio 九州大学, 歯学研究科, 教授 (90202952) ; TSURU Kanji 九州大学, 歯学研究科, 准教授 (50314654)
• Project Period (FY): 2011 – 2013
• Keywords: 複合膜 / 骨置換 / 骨伝導 / 破骨細胞

Research Abstract

We developed the GBR membrane which has not only the function to interrupt an epithelium cell but also an increase and the differentiation of the osteoblasts positively, and the resolution was absorbed in harmony with finally bone remodeling in vivo, and was completely substituted for a bone by making CO3Ap and various cell growth factors composition in biodegradable high polymer PLGA. Furthermore, using a cell and a laboratory animal, I demonstrated the usefulness of the materials which I developed.

Research Products

• [Journal Article] Bone formation and osseointegration with titanium implant using granular-and block-type porous hydroxyapatite ceramics (2013)
  • Author(s): Minami, M., Takechi, M., Ohta, K., Ohta, A., Ninomiya, Y., Takamoto, M., Fukui, A., Tada, and Kamata, N
  • Journal Title: Dental Materials Journal Volume: 32(5) Pages: 753-760
  • Peer Reviewed
• [Journal Article] Risk of bacterial contamination of bone harvesting devices used for autogenous bone graft in implant surgery (2013)
  • Author(s): Takamoto, M., Takechi, M., Ohta, K., Ninomiya, Y., Ono, S., Shigeishi, H., Tada, and Kamata, N
  • Journal Title: Head Face Med Volume: 11
  • DOI: 10.1186/1746-160X-9-3
  • Peer Reviewed
• [Journal Article] 3-dimensional composite scaffolds consisting of apatite-PLGA-atelocollagen for bone tissue engineering (2012)
  • Author(s): Takechi, M., Ohta, K., Ninomiya, Y., Tada, M., Minami, M., Takamoto, M., Ohta, A., Nakagawa, T., Fukui, A., Miyamoto, Y. and Kamata, N
  • Journal Title: Dental Materials Journal Volume: 31(3) Pages: 465-471
  • Peer Reviewed
• [Journal Article] Clinical evaluation of novel interconnected porous hydroxyapatite ceramics (IP-CHA) in a maxillary sinus floor augmentation procedure (2012)
  • Author(s): Shigeishi, H., Takechi, M., Nishimura, M., Takamoto, M., Minami, M., Ohta, K. and Kamata, N
  • Journal Title: Dental Materials Journal Volume: 31(1) Pages: 54-60
  • Peer Reviewed
• [Presentation] インプラント埋入時におけるISQ値と埋入トルク値に関する臨床統計学的検討 (2013)
  • Author(s): 小野重弘、二宮嘉昭、太田耕司、中川貴之、高本愛、武知正晃
  • Organizer: 第17回日本顎顔面インプラント学会総会・学術大会
  • Place of Presentation: 東京
  • Year and Date: 2013-11-30
• [Presentation] 骨造成術において各種器具により採取した自家骨中細菌数の比較 (2013)
  • Author(s): 高本愛、太田耕司、二宮嘉昭、小野重弘、中川貴之、太田彰、久保薗和美、武知正晃
  • Organizer: 第33回日本口腔インプラント学会中国・四国支部総会・学術大会
  • Place of Presentation: 米子
  • Year and Date: 2013-11-24
• [Presentation] 炭酸アパタイト/poly(D,Lactide-co-glycolic acid)複合体の各種物性およびin vitro骨吸収性の評価 (2012)
  • Author(s): 太田彰、武知正晃、太田耕司、南正彦、波多野寛子、都留寛治、石川邦夫、鎌田伸之
  • Organizer: 第66回日本口腔科学会学術集会
  • Place of Presentation: 広島
  • Year and Date: 2012-05-18
• [Presentation] 炭酸アパタイト-PLGA複合体による新規骨再生材料の開発 (2011)
  • Author(s): 太田彰、武知正晃、太田耕司、二宮嘉昭、中川貴之、多田美里、南正彦、高本愛、都留寛治、石川邦夫、鎌田伸之
  • Organizer: 第33回日本バイオマテリアル学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-11-22