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2013 Fiscal Year Final Research Report

Establishment of the newly bone regeneration therapy using polyhedra particles immobilized BMP-2 as a controlled release carrier for BMP-2

Research Project

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Project/Area Number 23593002
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionKanagawa Dental College

Principal Investigator

OMI yasushi  神奈川歯科大学, 歯学部, 助教 (10318892)

Co-Investigator(Kenkyū-buntansha) MATSUMOTO Goichi  神奈川歯科大学, 歯学部, 准教授 (60199867)
Project Period (FY) 2011 – 2013
Keywords骨再生治療 / バイオマテリアル / 多角体 / BMP-2 / 徐放 / アテロコラーゲンスポンジ
Research Abstract

Bombyx mori cypovirus particles are embedded in micrometer-sized protein crystals called polyhedra and can remain infectious in harsh environmental conditions for years. But the remarkable stability of polyhedra can be applied on slow-release carriers of cytokines for tissue engineering. Here we show the complete healing in critical-sized bone defects by bone morphogenetic protein-2 (BMP-2) encapsulated polyhedra. Although absorbable collagen sponge (ACS) safely and effectively delivers recombinant human BMP-2 (rhBMP-2) into healing tissue, the current therapeutic regimens release rhBMP-2 at an initially high rate after which the rate declines rapidly. ACS impregnated with BMP-2 polyhedra had enough osteogenic activity to promote complete healing in critical-sized bone defects, but ACS with a high dose of rhBMP-2 showed incomplete bone healing, indicating that polyhedral microcrystals containing BMP-2 promise to advance the state of the art of bone healing.

  • Research Products

    (5 results)

All 2014 2013 2012 2011 Other

All Journal Article (3 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] Control of angiogenesis by VEGF and endostatin - encapsulated protein microcrystals and inhibition of tumor angiogenesis2014

    • Author(s)
      Matsumoto G, Hirohata R, Hayashi K, Sugimoto Y, Kotani E, Shimabukuro J, Hirano T, Nakajima Y, Kawamata S, Mori H
    • Journal Title

      Biomaterials

      Volume: 35 Pages: 1326-1333

  • [Journal Article] Gelatin powders accelerate the resorption of calcium phosphate cement and improve healing in the alveolar ridge2013

    • Author(s)
      Matsumoto G, Sugita Y, Kubo K, Yoshida W, Ikada Y, Sobajima S, Neo M, Maeda H, Kinoshita Y
    • Journal Title

      J Biomater Appl

      Volume: 28 Pages: 1316-1324

  • [Journal Article] Bone regeneration by polyhedral microcrystals from silkworm virus2012

    • Author(s)
      Matsumoto G, Ueda T, Shimoyama J, Ijiri H, Omi Y, Yube H, Sugita Y, Kubo K, Maeda H, Kinoshita Y, Arias DG, Shimabukuro J, Kotani E, Kawamata S, Mori H
    • Journal Title

      Sci Rep

      Volume: 2 Pages: 935

    • DOI

      10.1038/srep00935

  • [Presentation] BMP-2固定化多角体を用いた新規骨再生療法の開発2011

    • Author(s)
      松本剛一、下山淳子、久保田英朗、窪田展久、川股亮太、久保勝俊、木下靭彦、前田初彦
    • Organizer
      第65回日本口腔科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20110421-22
  • [Remarks]

    • URL

      http://www.nature.com/srep/2012/121206/srep00935/full/srep00935.html/

URL: 

Published: 2015-07-16  

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