2013 Fiscal Year Final Research Report
Spontaneously developed osteoarthritis in the temporomandibular joint in STR/ort mice
| Project/Area Number |
23593004
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Satsuki 日本歯科大学, 生命歯学部, 准教授 (10386253)
KUMAGAI Kenichi 鶴見大学, 歯学部, 助教 (10518129)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 変形性顎関節症 / STR/Ortマウス / 顎関節OA |
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| Research Abstract |
TMJs from 11 STR/ort mice euthanized at 30, 40, 50, 60, or 70 weeks of age, and from six CBA mice euthanized at 30, 40, or 60 weeks of age were examined. Toluidine blue and tartrate-resistant acid phosphatase staining were used to assess histological changes in the articular cartilage. Morphological changes in the articular cartilage of the TMJ were evaluated using micro-computed tomography. At the age of 40 to 50 weeks, 66% of STR/ort mice losed of articular cartilage on histology, with cavitation and erosion of the exposed bone and gradual changes in condylar shape. Furthermore, osteoarthritic morphological changes, and structural alterations were observed by micro-computed tomography. The STR/ort mouse strain appears to be developed spontaneous osteoarthritis-like lesions in the TMJ with age, and would be a useful model to study the pathogenesis of TMJ osteoarthritis.
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